Results 81 to 90 of about 17,696,992 (301)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Exploring the relationship between physical activity knowledge, health outcomes expectancies, and behavior [PDF]

open access: yes, 2011
Background: Despite clear health benefits of physical activity, previous research has been limited in linking knowledge of physical activity recommendations to actual behavior.
Bauman, Adrian   +2 more
core  

Structural insights and biological activities of flavonoids: Implications for novel applications

open access: yesFood Frontiers
Flavonoids are a major class of polyphenolic compounds that occur naturally in plants and are widely distributed in various dietary products. Flavonoids exhibit prominent physicochemical properties and biological activities, thereby garnering ...
Sheng Tang   +7 more
doaj   +1 more source

Phomentrioloxin, a Fungal Phytotoxin with Potential Herbicidal Activity, and its Derivatives: A Structure?Activity Relationship Study

open access: yes, 2013
Phomentrioloxin is a phytotoxic geranylcyclohexenetriol produced in liquid culture by Phomopsis sp. (teleomorph: Diaporthe gulyae), a potential mycoherbicide proposed for the control of the annual weed Carthamus lanatus.
Gavin Ash   +14 more
core   +1 more source

The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification [PDF]

open access: yes, 2009
*Objective:* To investigate the best statistical models that describe the effect of physical activity on BMI. *Design:* Cross-sectional analyses of physical activity and BMI data.Subjects: 107 obese, overweight, and healthy college students ...
Gizachew Tiruneh, Gizachew Tiruneh
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview

open access: yesInternational Journal of Nanomedicine, 2019
Bruna Lallo da Silva,1 Marina Paiva Abuçafy,1 Eloisa Berbel Manaia,1 João Augusto Oshiro Junior,1 Bruna Galdorfini Chiari-Andréo,1,2 Rosemeire CL R Pietro,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of ...
Lallo da Silva B   +6 more
doaj  

Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics

open access: yesMedComm – Oncology
Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity.
Tian‐Hua Wei   +18 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

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