Results 101 to 110 of about 3,704,653 (352)
Alcohol Dehydrogenase Structure-Activity Relationships
Journal of Biological Chemistry, 1972 Substituent constants and regression analysis have been employed in a study of the structure-activity relationship of binding and inhibition of alcohol dehydrogenase with small molecules. Using this technique, it is possible to separate the hydrophobic, electronic, and steric roles of substituents in the interaction of the small molecules with the ...
C, Hansch, J, Schaeffer, R, Kerley
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Medicine in Drug DiscoveryIndole is one of the naturally occurring nitrogen-containing bicyclic heterocyclic ring systems where benzene and pyrrole rings are fused. It has been demonstrated to exhibit versatile biological activities.
Biplab Debnath +9 more
doaj +1 more source
Chemistry Central Journal, 2017 Background A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a–t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate aromatic amine.
Mostafa M. Ghorab +5 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecules, 2014 As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activities
Rui Yang +6 more
doaj +1 more source
Peptide Bacteriocins - Structure Activity Relationships
Current Topics in Medicinal Chemistry, 2015 With the growing concerns in the scientific and health communities over increasing levels of antibiotic resistance, antimicrobial peptide bacteriocins have emerged as promising alternatives to conventional small molecule antibiotics. A substantial attention has recently focused on the utilization of bacteriocins in food preservation and health safety ...
Etayash, Hashem +3 more
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Impact of soil management on the functional activity of microbial communities associated to cork oak rhizosphere [PDF]
, 2007 The microbial ecology of cork oak rhizosphere was investigated using the Biolog community level physiological profile (CLPP) that provides a unique metabolic fingerprint helpful for the characterization of complex microbial communities.
Caredda, Marco +3 more
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