Results 91 to 100 of about 3,704,653 (352)
The Term Structure of Interest Rates and Monetary Policy during a Zero Interest Rate Period [PDF]
This paper empirically evaluates the validity of the term structure of interest rates in a low interest rate environment using high-frequency Japanese data.
Nagayasu, Jun
core
An examination of the relationship between firm size and export activity in the New Zealand lumber industry : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Development Studies, Massey University [PDF]
, 1993 This thesis explores the relationship between export activity and firm size, with specific reference to New Zealands lumber industry. The main purpose of this investigation is to identify firm characteristics which link firm size to export behavior. This
Craw, Michael Curtis
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Synthesis and activity of novel indole derivatives as inhibitors of CD38
Acta Pharmaceutica Sinica B, 2013 CD38 is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues, regulating a wide range of physiological functions. Beginning with the previously reported compound 1, an inhibitor of human CD38 NADase, we synthesized a series of ...
Dongying Wu +7 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics
MedComm – OncologyJanus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity.
Tian‐Hua Wei +18 more
doaj +1 more source
The Structure-Activity Relationship of the Antioxidant Peptides from Natural Proteins
Molecules, 2016 Peptides derived from dietary proteins, have been reported to display significant antioxidant activity, which may exert notably beneficial effects in promoting human health and in food processing.
Tang-Bin Zou +4 more
doaj +1 more source
, 2013 Interrelated Two-way Clustering (ITC) is an unsupervised clustering method developed to divide samples into two groups in gene expression data obtained through microarrays, selecting important genes simultaneously in the process.
Basak, Subhash C. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecules, 2017 In this study, we tested eight naturally-occurring flavonoids—three flavanones and five flavones—for their possible antibacterial properties against four Gram-positive and four Gram-negative bacteria.
Javier Echeverría +4 more
doaj +1 more source