Results 71 to 80 of about 3,704,653 (352)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF AMIDE DERIVATIVES FROM ACRYLOPIMARIC ACID

BioResources, 2012
This paper reports on the synthesis of a series of amide derivatives from acrylopimaric acid (APA). The derivatives contained aromatic groups and were characterized by IR, 1HNMR, MS, and elemental analysis.
Jian Li,, Xiaoping Rao,, Shibin Shang,, Yanqing Gao, , Jie Song   +4 more
doaj  

A practical overview of quantitative structure-activity relationship [PDF]

, 2009
Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library.
Isarankura-Na-Ayudhya, Chartchalerm, Naenna, Thanakorn, Nantasenamat, Chanin, Prachayasittikul, Virapong   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Bioinformatics, bacterial expression and enzyme activity analyses of dichloromethane dehalogenase from Methylobacterium rhodesianum H13

Biotechnology & Biotechnological Equipment, 2020
Dechlorination is the key step in biological degradation of dichloromethane (DCM), which is catalyzed by the enzyme DCM dehalogenase. In this study, the detailed structure and function of DCM dehalogenase in Methylobacterium rhodesianum H13 were ...
Jianguo Ni, Ying Liu, Chenjia Shen, Dongzhi Chen, Yueyong Xin, Qi Liu   +5 more
doaj   +1 more source

Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase [PDF]

, 2017
Human p300 is a polyhedric transcriptional coactivator, playing a crucial role by acetylating histones on specific lysine residues. A great deal of evidences shows that p300 is involved in several diseases as leukemia, tumors and viral infection.
Alberter, Arif, Artico, Azoulay, Balasubramanyam, Barreca, Brown, Chen, Choi, Costi, Costi, Dekker, Devipriya, Eckner, Farid, Gao, Getun, Ghizzoni, Granchi, Iyer, Iyer, Iyer, Kurdistani, Ligeret, Liu, Maddox, Mai, Maksimoska, Marcu, Noh, Osman, Ravindra, Robles, Sherman, Sherman, Sterner, Stimson, Thompson, Tintori, Toth, Tuccinardi, Valor, Vempati, Wang, Wong, Yasufumi, Zhao, Zheng, Zheng, Zhu   +49 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Structure-activity relationships of estrogens.

Environmental Health Perspectives, 1985
The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor.
V C, Jordan, S, Mittal, B, Gosden, R, Koch, M E, Lieberman   +4 more
openaire   +2 more sources

What turns galaxies off? The different morphologies of star-forming and quiescent galaxies since z~2 from CANDELS [PDF]

, 2011
We use HST/WFC3 imaging from the CANDELS Multicycle Treasury Survey, in conjunction with the Sloan Digital Sky Survey, to explore the evolution of galactic structure for galaxies with stellar masses >3e10M_sun from z=2.2 to the present epoch, a time span
Abazajian, Aday R. Robaina, Anton Koekemoer, Arjen van der Wel, Avishai Dekel, Baugh, Bell, Bell, Bell, Bell, Bell, Benson, Bezanson, Blanton, Blanton, Brammer, Brammer, Brown, Bundy, Bundy, Cameron, Casey Papovich, Cassata, Cheung, Christina C. Williams, Christopher J. Conselice, Dale Kocevski, Daniel H. McIntosh, David C. Koo, Davis, Dekel, Donley, Drory, Duilia de Mello, Edmond Cheung, Elizabeth J. McGrath, Eric F. Bell, Faber, Fioc, Franx, Furusawa, Graham, Grogin, Győry, Gültekin, Hans-Walter Rix, Harry Ferguson, Hoffman, Hopkins, Hopkins, Häring, Häussler, Häußler, Ilbert, James S. Dunlop, Jennifer Lotz, Jessica Herrington, Jeyhan Kartaltepe, Johansson, Kannappan, Karim, Kartaltepe, Khochfar, Koekemoer, Kriek, Kriek, Kriek, Lee, Lupton, Magorrian, Martig, Mauro Giavalisco, McGrath, Moster, Naab, Noeske, Norman Grogin, Pannella, Papovich, Papovich, Papovich, Patel, Peng, Peng, Peng, Peng, Prochaska, Rix, Robaina, Ruhland, S. M. Faber, Salim, Salim, Schlegel, Scoville, Simard, Skrutskie, Somerville, Springel, Stijn Wuyts, Stockton, Strateva, Szomoru, Sérsic, Tal, Taylor, Taylor, Tremonti, Tremonti, van den Bergh, van der Wel, van der Wel, van der Wel, van der Wel, van Dokkum, van Dokkum, Wake, Wake, Weinmann, Whitaker, Whitaker, Williams, Williams, Wuyts, Wuyts, Wuyts, Wuyts, Wuyts, Yang, Yi, Zheng   +130 more
core   +5 more sources