Results 51 to 60 of about 22,404,851 (343)

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

open access: yesScientific Reports, 2022
Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models,
Tom Luijts   +10 more
doaj   +1 more source

FIVEBRANE STRUCTURES

open access: yesReviews in Mathematical Physics, 2009
We study the cohomological physics of fivebranes in type II and heterotic string theory. We give an interpretation of the one-loop term in type IIA, which involves the first and second Pontrjagin classes of spacetime, in terms of obstructions to having bundles with certain structure groups.
Sati, Hisham   +2 more
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Unusual Thermo‐Enhanced Second Harmonic Generation in Organic Configurationally‐Locked Polyene Crystals

open access: yesAdvanced Science
To modulate nonlinear optical (NLO) effects of crystalline material holds great application potential in the photoelectronic and optical fields. Organic configurationally‐locked polyene represents an exciting NLO family with large second harmonic ...
Yi Liu   +9 more
doaj   +1 more source

A Modified Strain-Rate-Dependent Spring-Mass Model for Response Prediction of Composite Laminates Subjected to Low-Velocity Impact

open access: yesInternational Journal of Aerospace Engineering, 2023
A modified strain-rate dependent (SRD) spring-mass model was first developed to capture the strain rate effect on response prediction of fiber-reinforced polymer (FRP) laminates subjected to low-velocity impact (LVI).
Qiao Zhu, Zhefeng Yu
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Pyro‐Phototronic Effect Induced Circularly Polarized Light Detection with a Broadband Response

open access: yesAdvanced Science
Photopyroelectric‐based circularly polarized light (CPL) detection, coupling the pyro‐phototronic effect and chiroptical phenomena, has provided a promising platform for high‐performance CPL detectors.
Qianwen Guan   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Experimental Research on Damping Effect of Double-Layer Tuned Mass Damper for High-Rise Structure

open access: yesShock and Vibration, 2021
A double-layer tuned mass damper (DTMD) has advantages of wide damping frequency band and strong robustness. At present, there is a lack of seismic design methods for high-rise structures based on DTMDs.
Botan Shen   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

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