Results 51 to 60 of about 8,160,938 (248)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Structural Basis for the Interaction between p53 Transactivation Domain and the Mediator Subunit MED25

Molecules, 2018
Eukaryotic transcription initiation is mediated by interactions between transcriptional activators and the mediator coactivator complex. Molecular interaction of p53 transcription factor with mediator complex subunit 25 (MED25) is essential for its ...
Min-Sung Lee, Kyungeun Lim, Mi-Kyung Lee, Seung-Wook Chi   +3 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Mechanical properties of fiber reinforced concrete mixed with recycled fine aggregate: compressive, flexural, and tensile behavior

Discover Applied Sciences
Recycled fine aggregates (RFA), as a recyclable and reusable material, can help reduce the exploitation of natural resources and promote resource recycling.
Yanfen Gong, Shangxin Zhang, Hao Zhang, Chunling Yan, Songqiang Wan, Huicong Lu, Chongjin Li, Hongbo Xiao, Junhua Guo, Jingli Yang, Xingyao Wang, Han Song, Long Liu   +12 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Flexural behavior of RC beams strengthened with CFRP sheets and ECC layers

Discover Applied Sciences
To further enhance the flexural capacity and ductility of reinforced concrete (RC) beams, this study proposes an innovative strengthening method. This approach, referred to as Carbon Fiber Reinforced Polymer (CFRP) and Engineered Cementitious Composite ...
Xiaobing Hou, Ziyi Song, Han Song, Xingyao Wang, Junhua Guo, Songqiang Wan, Jingli Yang, Hongbo Xiao, Yanfen Gong, Long Liu   +9 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Evaluation of thermal effects in high-speed shifting tillage operations on share-point wear in sandy loam soil

Scientific Reports
A share-point is a cutting edge of the ploughshare, the crucial component of a horizontally reversible plough (HRP). Our previous trials in sandy loam soil indicated that severe abrasion/attrition wear with white materials appeared at the share-point ...
Yan-Chen Li, Dan-Yang Song, Lin Zhu, Xin-Yu Xie, Xin-Ran Wu, Hao-Ran Wang, Lu Liu   +6 more
doaj   +1 more source