Results 51 to 60 of about 8,196,711 (316)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Observation of counterion effects and dimensionality reduction in single-crystal (EDO-TTF)2SbF6 with ultrafast electron diffraction [PDF]

EPJ Web of Conferences, 2019
Femtosecond electron diffraction is used to resolve structural dynamics in single-crystal (EDO-TTF)2XF6 (X = P, Sb). The retarded and lower-dimensional dynamics of the latter illustrate the dominant role of counterion motion in stabilizing electron ...
Liu Lai Chung, Jiang Yifeng, Mueller-Werkmeister Henrike M., Lu Cheng, Moriena Gustavo, Ishikawa Manabu, Nakano Yoshiaki, Yamochi Hideki, Miller R. J. Dwayne   +8 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Quasi-static and dynamic mechanical properties of additively manufactured Al2O3 ceramic lattice structures: effects of structural configuration

Virtual and Physical Prototyping, 2022
Ceramic lattice structures (CLSs) are promising candidates for structural applications used in conventional and extreme environments because of their extraordinary properties.
Xueqin Zhang, Keqiang Zhang, Bin Zhang, Ying Li, Rujie He   +4 more
doaj   +1 more source

Structures and Structural Information [PDF]

Proceedings of the IS4SI 2017 Summit DIGITALISATION FOR A SUSTAINABLE SOCIETY, Gothenburg, Sweden, 12–16 June 2017., 2017
Structures play a crucial role in the world. They define things and thoughts, processes and functions, images and ideas. The goal of this research is to study structural information, which is intrinsically connected to structures. Here we present two approaches. In one of them, structural information is information in structures.
Rainer Feistel, Mark Burgin
openaire   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Structural Basis for the Interaction between p53 Transactivation Domain and the Mediator Subunit MED25

Molecules, 2018
Eukaryotic transcription initiation is mediated by interactions between transcriptional activators and the mediator coactivator complex. Molecular interaction of p53 transcription factor with mediator complex subunit 25 (MED25) is essential for its ...
Min-Sung Lee, Kyungeun Lim, Mi-Kyung Lee, Seung-Wook Chi   +3 more
doaj   +1 more source

Large-scale material extrusion-based additive manufacturing of short carbon fibre-reinforced silicon carbide ceramic matrix composite preforms

Virtual and Physical Prototyping, 2023
Large-scale short carbon fibre-reinforced silicon carbide (Csf/SiC) ceramic matrix composites (CMCs) have important applications in the field of aerospace engineering.
Wenqing Wang, Xiong Gao, Lu Zhang, Qingsong Ma, Suwen Li, Zengchan Li, Chujing Shen, Gang Wang, Rujie He   +8 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source