Results 61 to 70 of about 4,627,155 (265)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Engineering Active Metal and Nonmetal Sites in Porous Structures of Metal‐Hydroxide Clusters for Enhanced D2/H2 Uptake and Separation

Advanced Science
Efficient deuterium separation from hydrogen isotopic mixtures poses a significant challenge due to the nearly identical physicochemical properties of D2 and H2.
Zhuozhou Xie, Zhu Zhuo, Zi‐Ang Nan, Qing Li, Wenlin Wu, Yunzhe Zhou, Zi‐Xiu Lu, Jin Liu, Luyao Liu, Wenjing Wang, Daqiang Yuan, You‐Gui Huang   +11 more
doaj   +1 more source

Structural Basis for the Interaction between p53 Transactivation Domain and the Mediator Subunit MED25

Molecules, 2018
Eukaryotic transcription initiation is mediated by interactions between transcriptional activators and the mediator coactivator complex. Molecular interaction of p53 transcription factor with mediator complex subunit 25 (MED25) is essential for its ...
Min-Sung Lee, Kyungeun Lim, Mi-Kyung Lee, Seung-Wook Chi   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Flexural behavior of RC beams strengthened with CFRP sheets and ECC layers

Discover Applied Sciences
To further enhance the flexural capacity and ductility of reinforced concrete (RC) beams, this study proposes an innovative strengthening method. This approach, referred to as Carbon Fiber Reinforced Polymer (CFRP) and Engineered Cementitious Composite ...
Xiaobing Hou, Ziyi Song, Han Song, Xingyao Wang, Junhua Guo, Songqiang Wan, Jingli Yang, Hongbo Xiao, Yanfen Gong, Long Liu   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Mechanical properties of fiber reinforced concrete mixed with recycled fine aggregate: compressive, flexural, and tensile behavior

Discover Applied Sciences
Recycled fine aggregates (RFA), as a recyclable and reusable material, can help reduce the exploitation of natural resources and promote resource recycling.
Yanfen Gong, Shangxin Zhang, Hao Zhang, Chunling Yan, Songqiang Wan, Huicong Lu, Chongjin Li, Hongbo Xiao, Junhua Guo, Jingli Yang, Xingyao Wang, Han Song, Long Liu   +12 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluation of thermal effects in high-speed shifting tillage operations on share-point wear in sandy loam soil

Scientific Reports
A share-point is a cutting edge of the ploughshare, the crucial component of a horizontally reversible plough (HRP). Our previous trials in sandy loam soil indicated that severe abrasion/attrition wear with white materials appeared at the share-point ...
Yan-Chen Li, Dan-Yang Song, Lin Zhu, Xin-Yu Xie, Xin-Ran Wu, Hao-Ran Wang, Lu Liu   +6 more
doaj   +1 more source

Structural Invariants, Structural Kinds, Structural Laws [PDF]

, 2012
The paper has three parts. In the first part ExtOSR, an extended version of Ontic Structural Realism, will be introduced. ExtOSR considers structural properties as ontological primitives, where structural properties are understood as comprising both relational and structurally derived intrinsic properties or structure invariants.
openaire   +1 more source