Results 61 to 70 of about 8,196,711 (316)

Benchmarking tomographic acquisition schemes for high-resolution structural biology

open access: yesNature Communications, 2020
Here the authors systematically benchmark cryo-electron tomography acquisition schemes to optimize the attainable resolution for subtomogram averaging, and find that dose-symmetric acquisition with even angular sampling provides a better outcome than ...
Beata Turoňová   +7 more
doaj   +1 more source

Nonlinear Dynamic Responses of a Rotor-Bearing System with Eccentric Squeeze Film Dampers

open access: yesInternational Journal of Aerospace Engineering, 2023
A squeeze film damper (SFD) is a commonly used component in aeroengine support structures. However, eccentric SFDs are often employed in practical applications.
Jiaqi Han   +4 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Mechanical properties of fiber reinforced concrete mixed with recycled fine aggregate: compressive, flexural, and tensile behavior

open access: yesDiscover Applied Sciences
Recycled fine aggregates (RFA), as a recyclable and reusable material, can help reduce the exploitation of natural resources and promote resource recycling.
Yanfen Gong   +12 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

TheStructure, theWholeStructure, and Nothingbutthe Structure?

open access: yesPhilosophy of Science, 2006
This paper is structured around the three elements of the title. Section 2 claims that (a) structuresneedobjects and (b) scientific structuralism should focus onin restructures. Therefore, pure structuralism is undermined. Section 3 discusses whether the world has ‘excess structure’ over the structure of appearances.
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Evaluation of thermal effects in high-speed shifting tillage operations on share-point wear in sandy loam soil

open access: yesScientific Reports
A share-point is a cutting edge of the ploughshare, the crucial component of a horizontally reversible plough (HRP). Our previous trials in sandy loam soil indicated that severe abrasion/attrition wear with white materials appeared at the share-point ...
Yan-Chen Li   +6 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

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