Results 71 to 80 of about 8,389,285 (295)

Structural Basis for the Interaction between p53 Transactivation Domain and the Mediator Subunit MED25

Molecules, 2018
Eukaryotic transcription initiation is mediated by interactions between transcriptional activators and the mediator coactivator complex. Molecular interaction of p53 transcription factor with mediator complex subunit 25 (MED25) is essential for its ...
Min-Sung Lee, Kyungeun Lim, Mi-Kyung Lee, Seung-Wook Chi   +3 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Flexural behavior of RC beams strengthened with CFRP sheets and ECC layers

Discover Applied Sciences
To further enhance the flexural capacity and ductility of reinforced concrete (RC) beams, this study proposes an innovative strengthening method. This approach, referred to as Carbon Fiber Reinforced Polymer (CFRP) and Engineered Cementitious Composite ...
Xiaobing Hou, Ziyi Song, Han Song, Xingyao Wang, Junhua Guo, Songqiang Wan, Jingli Yang, Hongbo Xiao, Yanfen Gong, Long Liu   +9 more
doaj   +1 more source

Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens [PDF]

, 2023
Brendan J. Mahoney, Andrew K. Goring, Yueying Wang, Poojita Dasika, Anqi Zhou, Emmitt Grossbard, Duilio Cascio, Joseph A. Loo, Robert Clubb   +8 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Mechanical properties of fiber reinforced concrete mixed with recycled fine aggregate: compressive, flexural, and tensile behavior

Discover Applied Sciences
Recycled fine aggregates (RFA), as a recyclable and reusable material, can help reduce the exploitation of natural resources and promote resource recycling.
Yanfen Gong, Shangxin Zhang, Hao Zhang, Chunling Yan, Songqiang Wan, Huicong Lu, Chongjin Li, Hongbo Xiao, Junhua Guo, Jingli Yang, Xingyao Wang, Han Song, Long Liu   +12 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Evaluation of thermal effects in high-speed shifting tillage operations on share-point wear in sandy loam soil

Scientific Reports
A share-point is a cutting edge of the ploughshare, the crucial component of a horizontally reversible plough (HRP). Our previous trials in sandy loam soil indicated that severe abrasion/attrition wear with white materials appeared at the share-point ...
Yan-Chen Li, Dan-Yang Song, Lin Zhu, Xin-Yu Xie, Xin-Ran Wu, Hao-Ran Wang, Lu Liu   +6 more
doaj   +1 more source

Deeply inelastic scattering structure functions on a hybrid quantum computer [PDF]

, 2020
Niklas Mueller, Andrey Tarasov, Raju Venugopalan   +2 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source