Results 71 to 80 of about 22,404,851 (343)

Progress and Challenges in Electromechanical Coupling of Radio Telescopes

International Journal of Antennas and Propagation, 2022
Radio astronomy is a discipline of dynamics and wonders. The vast universe has many secrets to unravel. As one of the important facilities in this discipline, radio telescopes play a key role in collecting astronomical data and unraveling mysteries. With
Yuefei Yan, Song Xue, Xinlan Hu, Peiyuan Lian, Qian Xu, Na Wang, Wulin Zhao, Yang Wu, Baoyan Duan, Congsi Wang   +9 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Development and mechanical performance evaluation of a novel red mud-based filler for tunnel invert backfilling

Scientific Reports
How to achieve large-scale resource utilization of red mud has become a worldwide challenge in environmental protection. This study developed a novel red mud-based filler to address the pollution issues associated with red mud stockpiling and meet the ...
Jiahe Yu, Junying Rao, Xiaolong Song, Pingyang Wu   +3 more
doaj   +1 more source

Superimposed Stress Calculation of Soil Underlying Anchor Beam considering Anisotropy and Strength Nonhomogeneity

Geofluids, 2022
Prestress anchor beams are an important reinforcement method for underground engineering and rock slopes, and they are crucial for maintaining the stability of civil engineering structures.
Fei Xu, Zhongshun Wang, Liming Zhou, Hemin Zheng, Bo Liu, Yuqiu Jiang, Daili Wang   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Random effects structure for confirmatory hypothesis testing: Keep it maximal.

Journal of Memory and Language, 2013
Linear mixed-effects models (LMEMs) have become increasingly prominent in psycholinguistics and related areas. However, many researchers do not seem to appreciate how random effects structures affect the generalizability of an analysis.
D. Barr, R. Levy, Christoph Scheepers, Harry J. Tily   +3 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source