Results 151 to 160 of about 1,344,305 (317)

Adaptive variation in avian eggshell gas conductance and structure across elevational gradients?

eLife
Many tropical bird species have restricted elevational distributions, potentially limited by how environmental conditions affect physiological processes. While some studies have examined adult physiology across elevations, relatively little attention has
David Ocampo, Carlos Daniel Cadena, Esteban Correa-Agudelo, Marcela Hernández Hoyos, Gustavo A Londoño   +4 more
doaj   +1 more source

Linguistic Variation and Change

A comprehensive study of variation and change, including current debates in the area.Intro -- Cover -- Copyright -- Contents -- Figures -- Tables -- Preface and acknowledgements -- Terminology and notation conventions -- Phonetic notation -- Part I ...
Kiesling, Scott F.
core  

Inter-species variation in bone mineral [PDF]

, 2011
Bone is a complex heterogeneous composite material with organic and inorganic components. The inorganic component; bone mineral, is a poorly crystalline, non-stoichiometric form of calcium hydroxylapatite.
Beckett, Sophie
core  

Variational structure of the zones of instability

Differential and Integral Equations, 2001
We give a variational characterization of the regions of stability and instability for planar Hamiltonian systems which are periodic in the time dependence, and convex in the momentum variables. In particular, we give necessary and sufficient conditions for stability, in terms of the Morse index of the variational problem with periodic or anti-periodic
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Seasonal and hydrologic variation influences habitat and functional structure of stream fish assemblages

Frontiers in Environmental Science
IntroductionHydrologic variability is a key driver of ecological structure in lotic systems, shaping habitat conditions, taxonomic diversity, and the functional traits that mediate species’ persistence and performance (e.g., reproductive success).
Joshua D. Tivin, Daniel D. Magoulick, Daniel D. Magoulick   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Power and bipower variation with stochastic volatility and jumps [PDF]

This paper shows that realised power variation and its extension we introduce here called realised bipower variation is somewhat robust to rare jumps.
Neil Shephard, Ole E. Barndorff-Nielsen
core