Results 91 to 100 of about 9,138,586 (300)

Development and Evolution of Crystallographic Software: From Standalone Tools to Intelligent Integrated Platforms

open access: yesCrystals
Crystallography is fundamental to elucidating the relationship between microscopic structure and macroscopic material properties, and its progress is closely associated with advances in computational tools and software. This review traces the development
Rui Yao, Rongrong Jia, Zhenjie Feng
doaj   +1 more source

Molecular structure of dimeric ethoxytin trichloride ethanol solvate

open access: yesMain Group Metal Chemistry, 2013
The title compound Sn2Cl6(OEt)2(HOEt)2, accidentally obtained as a side product from the reaction of 2,6-Mes2C6H3Li with SnCl4 in Et2O, was investigated by single crystal X-ray diffraction.
Beckmann Jens   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Creating Security and Stability in Afghanistan and the Region

open access: yes, 2006
Recommendations in this report address issues related to ongoing state-building efforts in Afghanistan in the areas of security, rule of law, mobilization of the economy, regional relations, and trans-border issues including infrastructure and energy ...
Liechtenstein Institute on Self-Determination
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Using cryo-electron microscopy maps for X-ray structure determination [PDF]

open access: yes, 2018
X-ray crystallography and cryo-electron microscopy (cryo-EM) are complementary techniques for structure determination. Crystallography usually reveals more detailed information, while cryo-EM is an extremely useful technique for studying large-sized ...
Hao, Q   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Bioinspired Aerobic Oxidation to Functionalize the CD Ring of the Steroid Framework: Synthesis and Stereochemical Assignments of Gargalol C and Related Oxysterols

open access: yesChemistryEurope
Aerobic oxidation to insert oxygen functional groups into the CD ring of the steroid framework was investigated using several 5,6‐α‐epoxysterol precursors. Oxidation under Schenck‐ene conditions provided oxysterols with a hydroxyl group at either C8, C9,
Hinata Togo, Yui Kanda, Shoji Kobayashi
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

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