Results 151 to 160 of about 9,138,586 (300)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Machine Learning Accelerates Crystallization for Structure Determination. [PDF]

Angew Chem Int Ed Engl
Luan CZ, Wang XZ, Song JG, Gu Y, Wu J, Wang YT, Liang JF, Rao JL, Xie M, Nitschke JR, Li D.   +10 more
europepmc   +1 more source

AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network. [PDF]

Nat Methods
Fadini A, Li M, McCoy AJ, Banjara S, Okumura H, Napier E, Fontana P, Khan AR, Jovine L, Terwilliger TC, Read RJ, Hekstra DR, AlQuraishi M.   +12 more
europepmc   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Beyond PXRD Pattern Matching: Toward Rigorous Structure Determination in Covalent Organic Frameworks. [PDF]

Angew Chem Int Ed Engl
Nguyen HL.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

3D atomic structure determination with ultrashort-pulse MeV electron diffraction. [PDF]

IUCrJ
Hennicke V, Hachmann M, Klar PB, Reinke PYA, Pakendorf T, Meyer J, Delsim-Hashemi H, Barthelmess M, Thekku Veedu S, Fischer P, Rodrigues AC, Qelaj A, Tolstikova A, Yefanov O, Wernsmann J, Lemery F, Schubert R, de Diego I, Hayes S, Günther S, Falke S, Fröjd E, Mozzanica A, Palatinus L, Rossnagel K, Schmitt B, Chapman HN, Leemans W, Flöttmann K, Meents A.   +29 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel fusion tool to enable G protein-coupled receptor structure determination. [PDF]

Acta Crystallogr D Struct Biol
Shah NR, Oosterlaken M, Bisson C, Bertinelli M, Churchill-Angus AM, Hutchin A, Kopec J, Kotov V, McFarlane CR, Griss Pascualli E, Pavic A, Zebisch M, Fiez-Vandal C, Fabini E, Duclos S.   +14 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source