Results 91 to 100 of about 311,932 (330)
Metallo-intercalators and metallo-insertors [PDF]
, 2007 Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest.
Barton, Jacqueline K. +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
New microbial source of the antifungal allylamine “Terbinafine”
Saudi Pharmaceutical Journal, 2017 The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound.
Maged S. Abdel-Kader, Magdy M. Muharram
doaj +1 more source
Journal of Fungi, 2020 The genus Stromatoneurospora was erected in 1973 by Jong and Davis to accommodate the pyrophilic pyrenomycete Sphaeria phoenix and has traditionally been placed in the family Xylariaceae based on morphological features. However, no living culture of this
Kevin Becker +5 more
doaj +1 more source
Baculovirus expression: tackling the complexity challenge [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David +3 more
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
SOME PHENOLIC COMPOUNDS FROM STEM BARK OF MELINJO (GNETUM GNEMON) AND THEIR ACTIVITY TEST AS ANTIOXIDANT AND UV-B PROTECTION [PDF]
Isolation and structure elucidation of three phenolic compounds, namely 3,4-dimethoxychlorogenic acid (1), resveratrol (2), and 3-methoxyresveratrol (3) from stem bark of Melinjo (Gnetum gnemon) had been done. The isolation of those compounds was carried
Sri , Atun, Ph.D
core
, 2005 Background: With the increase in the number of genome sequencing projects, there is a concomitant exponential growth in the number of protein sequences whose function is still unknown.
MONTI, MARIA +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Publicness, Organisational Characteristics and Performance [PDF]
, 2013 This paper reports an exploratory study utilising a publicness model in which the impact of ownership, funding and mode of control on performance is moderated by organisational characteristics such as goals, structure and management.
B.Bozeman +7 more
core +1 more source