Results 151 to 160 of about 306,884 (301)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An integrated workflow for the structure elucidation of nanocrystalline powders. [PDF]

Commun Chem
Sabena C, Bravetti F, Miyauchi N, Nakafukasako M, Aoyama Y, Asakura K, Konuma K, Hashimoto M, Nishiyama Y, Chierotti MR.   +9 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Advancing Structure Elucidation with a Flexible Multi-Spectral AI Model. [PDF]

Angew Chem Int Ed Engl
Priessner M, Lewis RJ, Lemurell I, Johansson MJ, Goodman J, Janet JP, Tomberg A.   +6 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Structure Elucidation, Biosynthesis and Biological Evaluation of Neosorangicin A, a Member of the Sorangicin Family. [PDF]

J Nat Prod
Fries F, Walesch S, Jansen R, von Peinen K, Mehr L, Pätzold L, Karwehl S, Kany AM, Garcia R, Reinecke S, Haupenthal J, Stradal TEB, Bischoff M, Stadler M, Müller R, Herrmann J.   +15 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Structure Elucidation of Biflavones With Ether Bonds by NMR-Spectroscopy-Structure Revisions of Loniflavone and Methylloniflavone. [PDF]

Magn Reson Chem
Kunert O, Zangger K, Haas L, Alperth F, Pferschy-Wenzig E, Bucar F.   +5 more
europepmc   +1 more source

Synthesis and structure elucidation of

, 2010
The H-1 and C-13 NMR spectra of the new calix[4]arene-based tetraketone were completely assigned by one- and two-dimensional homo- and heteronuclear experiments (H-1-H-1 COSY, H-1-C-13 HMQC, and HMBC) at 400 and 100 MHz, respectively, at 25 degrees C standard pulse sequence.
Karakus, OO, Kazaz, C, Deligoz, H
openaire   +2 more sources