Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
An inflationary differential evolution algorithm for space trajectory optimization [PDF]
In this paper we define a discrete dynamical system that governs the evolution of a population of agents. From the dynamical system, a variant of Differential Evolution is derived.
Vasile, Massimiliano +2 more
core +3 more sources
Suboptimal solutions to network team optimization problems [PDF]
Smoothness of the solutions to network team optimization problems with statistical information structure is investigated. Suboptimal solutions expressed as linear combinations of elements from sets of basis functions containing adjustable parameters are ...
Gnecco, Giorgio, Sanguineti, Marcello
core
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
HIGH SPEED FUNCTIONALITY OPTIMIZATION OF FIVE-PHASE PM MACHINE USING 3RD HARMONIC CURRENT [PDF]
This project was supported by the Laboratory of Electrical Engineering and Power Electronics (L2EP) France. It is a successive cooperation project between the control team and optimization team of the laboratory .Some surrogate-assisted optimization ...
GONG, Jinlin +4 more
core
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Study on the key structure parameters of a gravity settling chamber based on a flow field simulation
A gravity settling chamber plays an important role in improving the effect of the dust removal when it is selected as a dust collector in a pneumatic cleaning system for cleaning a subway tunnel. The settling rate and the indexes evaluating the secondary
Xiaojing Liu +5 more
doaj +1 more source
Analysis of a Segmented Annular Coplanar Capacitive Tilt Sensor with Increased Sensitivity
An investigation of a segmented annular coplanar capacitor is presented. We focus on its theoretical model, and a mathematical expression of the capacitance value is derived by solving a Laplace equation with Hankel transform.
Jiahao Guo, Pengcheng Hu, Jiubin Tan
doaj +1 more source
Exploration and Optimization in Crystal Structure Prediction: Combining Basin Hopping with Quasi-Random Sampling [PDF]
We describe the implementation of a Monte Carlo basin hopping global optimization procedure for the prediction of molecular crystal structure. The basin hopping method is combined with quasi-random structure generation in a hybrid method for crystal ...
Shiyue, Yang, Graeme, Day
core +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source

