Results 71 to 80 of about 549,317 (264)
Applied SciencesNitrate pollution due to agricultural activities challenges the management of groundwater resources. The most popular technique used for groundwater vulnerability assessments is the DRASTIC.
Xianglong Hou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Numerical Simulation on the Erosive Wear inside the Subsea Capping Stack
Shiyou jixie, 2020 Subsea capping stack is a kind of emergency rescue device and it is used for emergency rescue after the failure of underwater well control. In order to understand the wear situations of subsea capping stack under different working conditions, its ...
Li Qian +4 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scientific ReportsAccurately characterizing the spatial distribution of heavy metals in lake surface sediments, analyzing their sources, and identifying potential ecological risks are important scientific supports for lake ecosystem management.
Kuanzhen Mao +10 more
doaj +1 more source
On the stability of an Optimal Coalition Structure
, 2010 The two main questions in coalition games are 1) what coalitions should form and 2) how to distribute the value of each coalition between its members. When a game is not superadditive, other coalition structures (CSs) may be more attractive than the grand coalition. For example, if the agents care about the total payoff generated by the entire society,
Airiau, S., Sen, S.
openaire +3 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source