Results 91 to 100 of about 2,103,567 (340)

Building Proteins in a Day: Efficient 3D Molecular Reconstruction

, 2015
Discovering the 3D atomic structure of molecules such as proteins and viruses is a fundamental research problem in biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising vision-based technique for structure estimation which attempts to ...
Brubaker, Marcus A., Fleet, David J., Punjani, Ali   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Numerical Simulation on the Erosive Wear inside the Subsea Capping Stack

Shiyou jixie, 2020
Subsea capping stack is a kind of emergency rescue device and it is used for emergency rescue after the failure of underwater well control. In order to understand the wear situations of subsea capping stack under different working conditions, its ...
Li Qian, Li Jiaojiao, Zhai Fenlou, Wu Guohui, Li Zhe   +4 more
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Source apportionment and ecological risk assessment of heavy metals in sediments of Dongping lake based on PCA-PMF model

Scientific Reports
Accurately characterizing the spatial distribution of heavy metals in lake surface sediments, analyzing their sources, and identifying potential ecological risks are important scientific supports for lake ecosystem management.
Kuanzhen Mao, Xinfeng Wang, Kaining Yu, Mingming Li, Yibing Wang, Ge Gao, Shitao Geng, Hongliang Song, Wenbin Ning, Hongyan An, Baizhong Yan   +10 more
doaj   +1 more source

Idempotent Structures in Optimization [PDF]

Journal of Mathematical Sciences, 2001
This survey may be considered as an abridged version of the monographs [\textit{V. N. Kolokoltsov} and \textit{V. P. Maslov}, ``Idempotent analysis and its applications to the optimal control'' (in Russian) (1994; Zbl 0857.49022); ``Idempotent analysis and its applications'' (English translation) (1998; Zbl 0941.93001)] updated with some of the more ...
openaire   +1 more source

Improving Organizations by Replacing the "Mechanical" Model with the "Organic" one [PDF]

Organizations are currently viewed as artificial structures. However, in our opinion, organizations seem to match a biological structure much better. This paper explores this new approach with some interesting conclusions and results: organizations aim ...
George MOLDOVEANU, Ion Gh. ROSCA, Octavian Thor PLETER   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Multi-objective Optimization of a Composite Material Propeller Structure

Hangkong gongcheng jinzhan, 2018
Reducing the weight and increasing the torsion stiffness are the two main pursuits in the engineering design work of propeller blade structure. And the application of composite materials has improved the designability of propeller structure.
Zhang Bihui, Li Xile, Zhou Bo
doaj   +1 more source

Computational design of nanophotonic structures using an adaptive finite element method

, 2016
We consider the problem of the construction of the nanophotonic structures of arbitrary geometry with prescribed desired properties. We reformulate this problem as an optimization problem for the Tikhonov functional which is minimized on adaptively ...
Beilina, L., Mpinganzima, L., Tassin, P.
core