Results 91 to 100 of about 9,024,995 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Empipe3D™ User’s Manual Version 4.0 -- PC

, 1997
Empipe3D is a powerful and friendly software system for automated electromagnetic (EM) design optimization, driving the 3D field solvers Ansoft HFSS and HP HFSS.
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core   +1 more source

Numerical Simulation on the Erosive Wear inside the Subsea Capping Stack

Shiyou jixie, 2020
Subsea capping stack is a kind of emergency rescue device and it is used for emergency rescue after the failure of underwater well control. In order to understand the wear situations of subsea capping stack under different working conditions, its ...
Li Qian, Li Jiaojiao, Zhai Fenlou, Wu Guohui, Li Zhe   +4 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Source apportionment and ecological risk assessment of heavy metals in sediments of Dongping lake based on PCA-PMF model

Scientific Reports
Accurately characterizing the spatial distribution of heavy metals in lake surface sediments, analyzing their sources, and identifying potential ecological risks are important scientific supports for lake ecosystem management.
Kuanzhen Mao, Xinfeng Wang, Kaining Yu, Mingming Li, Yibing Wang, Ge Gao, Shitao Geng, Hongliang Song, Wenbin Ning, Hongyan An, Baizhong Yan   +10 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Multi-objective Optimization of a Composite Material Propeller Structure

Hangkong gongcheng jinzhan, 2018
Reducing the weight and increasing the torsion stiffness are the two main pursuits in the engineering design work of propeller blade structure. And the application of composite materials has improved the designability of propeller structure.
Zhang Bihui, Li Xile, Zhou Bo
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Structure learning of Bayesian Networks using global optimization with applications in data classification [PDF]

, 2014
Bayesian Networks are increasingly popular methods of modeling uncertainty in artificial intelligence and machine learning. A Bayesian Network consists of a directed acyclic graph in which each node represents a variable and each arc represents ...
Mammadov, Musa, Taheri, Sona
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source