Results 101 to 110 of about 9,024,995 (297)

On the stability of an Optimal Coalition Structure

open access: yes, 2010
The two main questions in coalition games are 1) what coalitions should form and 2) how to distribute the value of each coalition between its members. When a game is not superadditive, other coalition structures (CSs) may be more attractive than the grand coalition. For example, if the agents care about the total payoff generated by the entire society,
Airiau, S., Sen, S.
openaire   +3 more sources

Second-order cone programming formulations for a class of problems in structural optimization

open access: yes, 2010
This paper provides efficient and easy to implement formulations for two problems in structural optimization as second-order cone programming (SOCP) problems based on the minimum compliance method and derived using the principle of complementary energy ...
Makrodimopoulos, A.   +2 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Structural Optimization [PDF]

open access: yes, 1975
Fleury, Claude   +1 more
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Risk−Based Cost−Benefit Optimization Design for Steel Frame Structures to Resist Progressive Collapse

open access: yesBuildings
The design of structures to resist progressive collapse primarily focuses on enhancing structural safety and robustness. However, given the low probability of accidental events, such designs often lead to a negative cost–benefit. To address this problem,
Feng Guo   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Optimizing the Location of 5G Network Base Stations Taking into Account Intra-System Interference

open access: yesProceedings of the International Conference on Applied Innovations in IT
This work is devoted to the structural optimization of 5G networks, specifically addressing the problem of base station (BS) placement optimization in indoor network deployment.
Serhii Siden   +5 more
doaj   +1 more source

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