Results 81 to 90 of about 2,103,567 (340)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Structure Optimization of a Grain Impact Piezoelectric Sensor and Its Application for Monitoring Separation Losses on Tangential-Axial Combine Harvesters

Sensors, 2015
Grain separation losses is a key parameter to weigh the performance of combine harvesters, and also a dominant factor for automatically adjusting their major working parameters.
Zhenwei Liang, Yaoming Li, Zhan Zhao, Lizhang Xu   +3 more
doaj   +1 more source

Identifying "communities" within energy landscapes

, 2004
Potential energy landscapes can be represented as a network of minima linked by transition states. The community structure of such networks has been obtained for a series of small Lennard-Jones clusters.
A. Wagner, Claire P. Massen, D. J. Wales, F. H. Stillinger, Jonathan P. K. Doye, S. N. Dorogovtsev   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Data-Driven Method for Determining DRASTIC Weights to Assess Groundwater Vulnerability to Nitrate: Application in the Lake Baiyangdian Watershed, North China Plain

Applied Sciences
Nitrate pollution due to agricultural activities challenges the management of groundwater resources. The most popular technique used for groundwater vulnerability assessments is the DRASTIC.
Xianglong Hou, Liqin Peng, Yuan Zhang, Yan Zhang, Yunxia Wang, Wenzhao Feng, Hui Yang   +6 more
doaj   +1 more source

Structural optimization [PDF]

, 1971
The non-linear programming algorithms for the minimum weight design of structural frames are presented in this thesis. The first, which is applied to rigidly jointed and pin jointed plane frames subject to deflexion constraints, consists of a search in a feasible design space.
openaire   +1 more source

Stanovení racionální struktury bezpeýnostní služby integrovaného logistického podporného systému založeného na regionálních logistikých klastrech [PDF]

, 2013
Development of an integrated logistical support system for all types of national security services requires the solution to a problem of definition its rational structure.
Sysoiev, Volodymyr Viktorovych
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Stock market as temporal network

, 2017
Financial networks have become extremely useful in characterizing the structure of complex financial systems. Meanwhile, the time evolution property of the stock markets can be described by temporal networks.
Bao, Weiqi, Li, Wei, Stanley, H. Eugene, Wang, Gang-Jin, Wang, Mingang, Zhao, Longfeng   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source