Results 41 to 50 of about 10,794,162 (307)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
First Total Synthesis of (–)-Merrillianin [PDF]
, 2023 The first total synthesis of (–)-merrillianin (1), which is a natural sesquiterpene with a tri- fused structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated.
Teppei, Kuboki +17 more
core +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Wavelets for intonation modeling in HMM speech synthesis [PDF]
, 2013 The pitch contour in speech contains information about different linguistic units at several distinct temporal scales. At the finest level, the microprosodic cues are purely segmental in nature, whereas in the coarser time scales, lexical tones, word ...
Suni, Antti Santeri +5 more
core
, 2009 Octahydro-1H-benzofuro[3,2-e]isoquinolines, which possess the ACNO partial structure of morphine, displayed potent oral analgesic and narcotic-antagonism activity.
Hsin, Ling-Wei; Chen, Chien-Wei; Chang, Li-Te +1 more
core +1 more source
Structure-Aware Shape Synthesis [PDF]
2018 International Conference on 3D Vision (3DV), 2018 We propose a new procedure to guide training of a data-driven shape generative model using a structure-aware loss function. Complex 3D shapes often can be summarized using a coarsely defined structure which is consistent and robust across variety of observations.
Elena Balashova 0001 +5 more
openaire +2 more sources
Asymmetric radical carboesterification of dienes
Nature Communications, 2021 Stereocontrol of C–O bond formation from a carbon-based radical is very difficult due to the rapid inversion of the carbon radical. Here the authors present a method to form chiral esters from conjugated dienes with copper and chiral PyBox ligands ...
Xiaotao Zhu +6 more
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Structured Synthesis for Probabilistic Systems [PDF]
, 2019 We introduce the concept of structured synthesis for Markov decision processes where the structure is induced from finitely many pre-specified options for a system configuration. The resulting synthesis problem is in general a nonlinear programming problem (NLP) with integer variables.
Nils Jansen 0001 +3 more
openaire +4 more sources