Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
How to Make a Fast, Efficient Bubble-Driven Micromotor: A Mechanical View
Micromachines, 2017 Micromotors, which can be moved at a micron scale, have special functions and can perform microscopic tasks. They have a wide range of applications in various fields with the advantages of small size and high efficiency.
Lisheng Liu +6 more
doaj +1 more source
Exchange biased surface acoustic wave magnetic field sensors
Scientific Reports, 2023 Magnetoelastic composites which use surface acoustic waves show great potential as sensors of low frequency and very low amplitude magnetic fields.
Viktor Schell +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Starch synthesis in arabidopsis. Granule synthesis, composition, and structure [PDF]
, 2002 The aim of this work was to characterize starch synthesis, composition, and granule structure in Arabidopsis leaves. First, the potential role of starch-degrading enzymes during starch accumulation was investigated.
Alison M. Smith +11 more
core +1 more source
Studies towards the total synthesis and structure elucidation of leiodolide A
, 2013 Leiodolide A is a unique natural product isolated from Pacific marine sponges which has provided an interesting target for total synthesis due to its complex structure and undefined stereochemistry. Although synthetic work towards the synthesis of sister
Mould, Katy M.
core +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An LLM‐Driven Approach for Power Grid Structure Synthesis and Visualization
Energy Conversion and EconomicsResearch in power system is persistently hampered by the scarcity of high‐fidelity, public grid data due to security and privacy constraints. Existing unimodal synthesis methods fail to harmonize physical laws, visual representations and semantic ...
Binye Ni +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
[O 9,24] [2.1.2.1] metacyclophane-9-ene, a “twin cyclophane”, and its dehydrogenation products - synthesis structure determination and 1 H-NMR-spectroscopy [PDF]
, 1985 Grützmacher H-F, Husemann W. [O 9,24] [2.1.2.1] metacyclophane-9-ene, a “twin cyclophane”, and its dehydrogenation products - synthesis structure determination and 1 H-NMR-spectroscopy. Tetrahedron Letters.
Husemann, Wolfram +3 more
core +1 more source