Results 111 to 120 of about 1,114,115 (315)
Basic Conceptual Structures Theory [PDF]
, 1994 Although the theory of Conceptual Structures is over 10 years old, basic notions (like canonical graphs) are far from settled and are subject to constant extensions and reformulations. However, most of these are done in an informal way, which doesn't help in clarifying the issues involved.
Michel Wermelinger, José Gabriel Lopes
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CoRR, 2018 We develop a novel formal theory of finite structures, based on a view of finite structures as a fundamental artifact of computing and programming, forming a common platform for computing both within particular finite structures, and in the aggregate for computing over infinite data-types construed as families of finite structures. A "finite structure"
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Field-theoretic approach to large-scale structure formation
, 2019 We develop a field-theoretic description of large-scale structure formation by taking the non-relativistic limit of a canonically transformed, real scalar field which is minimally coupled to scalar gravitational perturbations in longitudinal gauge.
Friedrich, Pavel +4 more
core +1 more source
Detecting stable adsorbates of (1S)-camphor on Cu(111) with Bayesian optimization
, 2020 Identifying the atomic structure of organic-inorganic interfaces is challenging with current research tools. Interpreting the structure of complex molecular adsorbates from microscopy images can be difficult, and using atomistic simulations to find the ...
Rinke, Patrick +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Term Structure of Interest Rates: Evidence and Theory [PDF]
The term structure of interest rates is an old topic. Over the years, both the hypotheses debated and the research techniques used have changed considerably. Two fairly recent developments which distinguish current research are the widespread adoption of
Angelo Melino
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
BuildingsIn this paper, the quasi-static reciprocating loading test was carried out for the T-stub steel middle column joints with blind-bolt connections. As the thickness of the T-stub steel increased, the damage failure modes were different.
Huanhuan Liu +4 more
doaj +1 more source