Results 121 to 130 of about 5,486,383 (294)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Interaction Between Atoms and Structured Light Fields

Atoms
Structured light encompasses a vast variety of light fields. It has unique properties such as non-uniform transverse intensity and a polarization pattern across their beam cross-sections.
Shreyas Ramakrishna, Stephan Fritzsche
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Structured random light

The thesis explores how to incorporate structured random light into information networks.In the quest to enhance the capacity and quality of information networks, structured random light has emerged as a promising option.
Li, Xiaofei
core   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Focus issue introduction: synergy of structured light and structured materials

, 2017
Structured light beams, such as optical vortices, vector beams, and non-diffracting beams, have been recently studied in a variety of fields, such as optical manipulations, optical telecommunications, nonlinear interactions, quantum physics, and 'super ...
Etienne Brasselet, MORITA, Ryuji, WANG, Jian, Takashige Omatsu, Ryuji Morita, Jian Wang, BRASSELET, Etienne, Natalia M. Litchinitser, OMATSU, Takashige, LITCHINITSER, Natalia   +9 more
core   +1 more source

Diversified multiplexing based on multi-dimensional light modulation of single-layered diatomic dielectric metasurface

New Journal of Physics
A single-layered diatomic metasurface (SDM) is proposed to manipulate multiple parameters of light field including the amplitude, phase and state of polarization and realize multiple channel holographic imaging.
Rui Wu, Xiquan Jiang, Kun Jiang, Shuangshuang Ding, Jingwen Ma, Xinpeng Gao, Changda Zhou, Guoli He, Shuyun Teng   +8 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Twist metrology with twisted light in fibers

Light: Advanced Manufacturing
A recent breakthrough of optical metrology is the all-fiber rotational Doppler velocimetry using twisted light, which offers a compact, reciprocal, and ultra-broadband solution for measuring the angular velocity of rotating objects.
Yijie Shen
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source