Results 111 to 120 of about 5,991,366 (246)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Development of a university student-led paediatric clinic in regional Queensland

, 2019
Introduction: As demand for occupational therapy student clinical placements increases, student-led clinics have become more prominent as an alternative model for practice education.
Pamela Meredith (9819350), Carolyn Unsworth (9841613), Narelle Henwood (9803489), Lachlan Kerley (9809975), Claudia Bielenberg (9781013), Desley Simpson (9834929), Maria O'Reilly (9824231)   +6 more
core  

Student Experiences and Perceptions of Participation in Student-Led Health Clinics: A Systematic Review

, 2019
Supervised student-led health clinics provide students with opportunities to develop practice skills with “real” people by delivering clinical services to underserved communities.
Briggs, Lynne, Fronek, Patricia
core   +1 more source

The effectiveness of a student-led outpatient rehabilitation clinic in a hospital setting

, 2017
Background: The challenge of meeting demand for effective outpatient services, in the presence of limited resources, is a long-term issue facing physiotherapy departments. The concept of student-led clinics increasing productivity has been suggested, but
Bowron, Paul, Buhagiar, Mark, Karunaratne, Sascha, Fortunato, Renee, Grady, Andrew, Chipchase, Lucy; id_orcid   +5 more
core   +1 more source

Chinese Graduate Health Science Students' Perceptions of Teaching Pedagogies on Their Educational Experience

Occupational Therapy International
This paper explores pedagogical approaches for teaching Chinese graduate health science students by identifying students' perceptions of teaching and learning strategies that support learning.
Jeryl D. Benson, Richard C. Simpson
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A Comprehensive Business Plan and Sustainability Model for a Student-Led Pro-Bono Clinic Enriching Students and Community Well-Being [PDF]

Student-led pro-bono clinics are often established to address the growing concerns of access to healthcare services, especially in underserved areas. Additionally, student-led pro-bono clinics are initiated to guide student learning and prepare students ...
Days, Kelsey T
core   +1 more source

Developing and evaluating a community‐driven intervention to promote uptake of HIV and contraception services among students enrolled in colleges and universities in Zimbabwe

Journal of the International AIDS Society
Introduction There is a growing appreciation that community‐led interventions are key to sustaining the HIV response and achieving HIV prevention and treatment targets.
Oppah Kuguyo, Lindiwe Mancitshana, Collin Mangenah, Mary K. Tumushime, Nancy Ruhode, Edward Matsikire, Jane Kalweo, Fern Terris‐Prestholt, Frances M. Cowan, Euphemia Lindelwe Sibanda   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source