Results 101 to 110 of about 5,961,755 (299)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

School engagement and student burnout among medical and health science students in Saudi Arabia-cross-sectional study

Scientific Reports
School engagement and burnout are contributing factors influencing academic student performance. Student burnout is a serious concern in higher education, where it can result in poor mental and physical health and school dropout.
Amal Mohammed Qasem Surrati, Walaa Abdullah Mumena, Shymaa Abdullah Damfo, Albraa Badr Alolayan, Marwan M. A. Aljohani, Abdulaziz Mofdy Almarwani, Hanaa Mohammed Surrati   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Student Engagement

This chapter explores student engagement in middle years education. Attention is drawn to the significant drop in student engagement during this period and the measurable impact this decline has on academic achievement. The authors examine factors contributing to student engagement/disengagement and provide a descriptive explanation for the ...
Jeffrey Thomas, Helen Egeberg, Roberto H. Parada, Danielle Tracey, Karen Martin   +4 more
  +5 more sources

Teacher - Student Interaction and its Relation to Nursing Administration Course Engagement among Nursing Students [PDF]

Egyptian Journal of Health Care
Background: Interactions between teachers and their students play a pivotal role in academic engagement as a general and course engagement especially.
Marwa Mohamed Abu El-Hassan, Rabab Mahmoud, Samah Mohamed   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effect of teacher–student relationship on academic engagement: the mediating roles of perceived social support and academic pressure

Frontiers in Psychology
Although previous research has established that a strong teacher–student relationship can enhance students’ academic engagement, the mechanisms underlying this effect remain less explored.
Xiangliang Liu
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The relationship between student engagement in school and teachers' disciplinary techniques [PDF]

Nastava i Vaspitanje
Student engagement in school is a multidimensional construct that includes behavioral, emotional, and cognitive components. This construct, alongside numerous other factors, is associated with a range of positive developmental outcomes that can serve to ...
Bogićević Dragana, Popović-Ćitić Branislava, Trajković Marija   +2 more
doaj   +1 more source