Results 61 to 70 of about 762,995 (253)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Undergraduate Education Abroad in Community Settings: Pedagogical Opportunities for Librarians [PDF]

, 2019
As undergraduate possibilities for study and service abroad increase and develop strategically to address local community needs in settings in the Global South, there is greater opportunity for academic librarians to contribute expertise in supporting ...
Kutner, Laurie
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Using a maturity model to move student engagement practices beyond the generational approach [PDF]

, 2013
This paper proposes that the generational approach to conceptualising first year student learning behaviour, while it has made a very useful contribution to understanding that behaviour, can be expanded upon.
Clarke, John, Creagh, Tracy, Nelson, Karen, Stoodley, Ian   +3 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Andragogy and the single session lecture: A critical reflection on the planning and delivery of a standalone postgraduate teaching event [PDF]

, 2011
This paper focuses on a lecture delivered each year to postgraduates within the Department of Information Science at City University. The teaching context is outlined at personal, institutional and national levels through which the challenges facing a ...
Poirier, L.
core  

Developing a Conceptual Framework for Student Learning during International Community Engagement

Journal of University Teaching and Learning Practice, 2016
University-community engagement often involves students engaging with people who experience multiple forms of disadvantage or marginalization. This is particularly true when universities work with communities in developing nations. Participation in these projects can be challenging for students. Assumptions about themselves, their professional practice,
Pink, Matthew A, Taouk, Youssef, Guinea, Stephen, Bunch, Katie, Flowers, Karen, Nightingale, Karen   +5 more
openaire   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Student Library and Technology Engagement Survey Summary Report: 2012 [PDF]

, 2013
Based on a framework established by two prior investigations of local academic communities to inform library operations the CCL Student Library & Technology Engagement Survey was designed to explore: how Claremont Colleges students use, perceive, and ...
Booth, Char, Lowe, M. Sara
core   +4 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source