Results 61 to 70 of about 2,203,622 (278)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Synthesis of activated carbon from cherry tree waste and its application in removing cationic red 14 dye from aqueous environments

Applied Water Science, 2023
The environment is threatened by a diversity of pollutants, and synthetic dyes are considered a foremost environmental pollutant among them. The characteristics detected for the dye, e.g., toxicity and carcinogenicity, have brought severe problems for ...
Roya Askari, Faezeh Mohammadi, Amir Moharrami, Shirin Afshin, Yousef Rashtbari, Mehdi Vosoughi, Abdollah Dargahi   +6 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Prevalence of Depression Among Medical Students of a Private Medical College in India [PDF]

, 2011
Background: Medical education can contribute to the development of depression in medical students which may have possible negative academic and professional consequences.
Lal, Amar, Singh, Ajit, Singh, Shekhar
core   +1 more source

International medical electives in selected African countries: A phenomenological study on host experience [PDF]

, 2018
Objectives: To explore the host experience on international medical electives at a selection of hospitals in low- and middle-income countries in Africa.
Craig, Pippa, Fotheringham, Elspeth, Tor, Elina   +2 more
core   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Medice, Cura Te Ipsum (Physician, Heal Thyself): A Documentary Film Exploring How the Passions of Medical Students Will Make Them Better and Healthier Physicians [PDF]

, 2019
It is a well documented, yet largely ignored fact that physicians, residents and medical students are experiencing a pandemic of depression, burnout, dissatisfaction, and suicide.
Emhoff, Ryan
core   +1 more source

Twelve tips for teaching brief motivational interviewing to medical students [PDF]

, 2018
Background: Shifting from paternalistic to patient-centred doctor-patient relationships has seen a growing number of medical programs incorporate brief motivational interviewing training in their curriculum. Some medical educators, however, are unsure of
Amy J. Bannatyne, Ashley C. Stark, Butler CC, De Visser R., Edwards EJ, Elizabeth J. Edwards, Kalish R, Miller WR, Miller WR, Prochaska J, Rollnick S, Rollnick S   +11 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Surgical management of congenital pouch colon in Lebanon: A case report and review of the literature

Radiology Case Reports
Congenital pouch colon (CPC) is a rare congenital abnormality, in which a pouch-like dilatation partially or completely replaces the colon, creating a fistula with the urogenital.
Amal Naous, MD, Christin Berjaoui, Medical Students, Malek Osta, Medical Students, Amar Hafez, MD, Khaldoun Sinno, MD   +4 more
doaj   +1 more source