Results 31 to 40 of about 53,878 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Promoting Internship Excellence: Key Strategies Employed by Pharmacy Schools for Successful Development

Integrated Pharmacy Research and Practice, 2023
Najmaddin AH Hatem Department of Clinical Pharmacy, College of Clinical Pharmacy, Hodeidah University, Al-Hudaydah, YemenCorrespondence: Najmaddin AH Hatem, Department of Clinical Pharmacy, College of Clinical Pharmacy, Hodeidah University, P.O. 3114, Al-
Hatem NAH
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A comparative study regarding antibiotic consumption and knowledge of antimicrobial resistance among pharmacy students in Australia and Sri Lanka.

PLoS ONE, 2019
IntroductionAntimicrobial resistance (AMR) is a major global health challenge. Pharmacists play a key role in the health care setting to support the quality use of medicines. The education and training of pharmacy students have the potential to impact on
M H F Sakeena, Alexandra A Bennett, Stephen J Carter, Andrew J McLachlan   +3 more
doaj   +1 more source

Pharmacy students attitude and perception toward working in community pharmacy in Saudi Arabia

Saudi Pharmaceutical Journal, 2020
Objective: The objective of this study is to determine the level of attitude and perception of Saudi pharmacy students toward working in community pharmacies after graduation and to assess cultural, educational, and job related barriers and limitations ...
Bander Balkhi, Ahmed Alghamdi, Abdulaziz Alhossan, Ali Alhamami, Yousif A. Asiri   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Pharmacy students’ initial career choices versus subsequent career paths: a cross-sectional study

BMC Medical Education
Background The pharmacy profession offers diverse career paths. Yet, pharmacy students may not be familiar with these various paths and may struggle to choose one that is best suited to their interests, goals, and values.
Roy Kanbar, Aline H. Saad, Imad F. Btaiche   +2 more
doaj   +1 more source

Measuring the empathy levels among pharmacy students: a journey toward enhancing effective communication and understanding in the pharmacist-patient relationship

Frontiers in Communication
BackgroundEmpathy is an essential skill for healthcare professionals, including pharmacists, because it improves person-centered care and treatment outcomes.
Alhareth Ahmad, Razan I. Nassar, Samar Thiab, Mohammad Alostath, Rania Aldarawish, Sofiyan Mohd Ramahi, Anas Abed, Ahmad A. Assiri   +7 more
doaj   +1 more source