Results 81 to 90 of about 69,193,478 (249)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Implementation of Kurikulum Merdeka in Learning English to Students With Special Needs at SMP Plus Rahmat Kediri

English Franca: Academic Journal of English Language and Education
This study aims to investigate the implementation of the Kurikulum Merdeka in English language learning for inclusive students. The research method used is descriptive qualitative with observation, interview, and documentation triangulation techniques ...
Esthi Mulyani R, Erwin Hari Kurniawan, Wawan Herry Setyawan   +2 more
doaj   +1 more source

Social participation of students with special educational needs in inclusive elementary schools

Specialusis Ugdymas, 2019
This article examines the social participation of students with special needs in four aspects, namely friendship, interaction, social self-perception, and  peers acceptance.
Marlina Marlina , Grahita Kusumastuti
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Problems Of Implementing Assessment Of Students With Special Needs In Elementary Schools Providing Inclusive Education

Journal of Education for Sustainability and Diversity
The purpose of this study was to obtain an overview of the problems faced or felt by teachers in the implementation of the assessment of students with special needs in primary schools providing inclusive education.
Mirnawati, Siti Jaleha
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Provision for students with learning difficulties in general colleges of further education - have we been going round in circles? [PDF]

, 2004
This is a PDF version of an article published in British journal of special education© 2006. The definitive version is available at www.blackwell-synergy.com.This article discusses the current situation for students with severe learning difficulties in ...
Wright, Anne-Marie
core   +1 more source

Dynamics of sulfate and nitrate in a temperate stream network: combining multi-isotope analysis and generalized linear mixed-effects models for precautionary conservation

Progress in Earth and Planetary Science
Environmental pollution in stream networks is a major concern. In this study, the effects of land-use and geological characteristics on basin-scale sulfate and nitrate dynamics in the Chikusa River basin, Hyogo, Japan, where substantial environmental ...
Lei Fujiyoshi, Ichiro Tayasu, Shiho Yabusaki, Takashi F. Haraguchi, Chikage Yoshimizu, Ken’ichi Ohkushi, Fumiko Furukawa, Masayuki Itoh, Tadashi Yokoyama, Hiromune Mitsuhashi   +9 more
doaj   +1 more source