Results 221 to 230 of about 1,025,164 (345)

Expression of Concern: MiR-124-3p helps to protect against acute respiratory distress syndrome by targeting p65. [PDF]

Biosci Rep
Liang Y, Xie J, Che D, Zhang C, Lin Y, Feng L, Chen J, Chen J, Chen L, Wu Z.   +9 more
europepmc   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

L’atelier d’Ai Weiwei : « Make it simple »

Perspective, 2014
Estelle Bories
doaj   +1 more source

Three-Dimensionally Printed, On-Demand, Patient-Specific Breast Models to Support Mastectomy Gross Examination: A Proof-of-Concept Study. [PDF]

Cureus
Kousidis P, Syrnioti A, Pavlidou F, Pliachas M, Nikolaidou A.   +4 more
europepmc   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

Advanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source

De l’atelier au monument et au musée

Perspective, 2014
Oskar Bätschmann, Aldo De Poli, Dario Gamboni, Daniel F. Herrmann, Giles Waterfield   +4 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Performance assessment of five artificial intelligence-based algorithms for automated tooth segmentation and labeling on intraoral scans. [PDF]

J Prosthodont
Cacho-Salvador GD, Burgos-Artizzu XP, García-Arranz J, González-Martín Ó, Oteo-Morilla C, Gallas-Torreira M, Cernadas E, Piedra-Cascón W.   +7 more
europepmc   +1 more source

Machine‐Learning‐Assisted Impedance Component Analysis Enables Standardizable Surface Protein Analysis of Extracellular Vesicles Using Engineered Nanovesicles

Advanced Science, EarlyView.
This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song, Neethu Ramakrishnan, Sehyeon Kim, Huiseop Lee, Youngeun Kwon, Jinsik Kim   +5 more
wiley   +1 more source

AI-Enforced Ultra-Large Virtual Screening Discovers Potent CD28 Binders. [PDF]

J Chem Inf Model
Upadhyay S, Roggia M, Yuan S, Cosconati S, Gabr MT.   +4 more
europepmc   +1 more source