Results 111 to 120 of about 48,598,601 (312)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Factors associated with drug addiction relapse in elderly adults in Iran: A cross-sectional study [PDF]

Journal of Nursing Reports in Clinical Practice
Drug addiction relapse always complicates the process of coping with the addiction. Being aware of drug addicts’ attitudes toward barriers to permanent withdrawal can significantly affect the prevention of addiction relapse.
Zahra Abedi, Yasaman Yaghobi, Parand Pourghane, Elnaz Faraji Nesfechi   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Relations Between Facebook Intrusion, Internet Addiction, Life Satisfaction, and Self-Esteem: a Study in Italy and the USA

International Journal of Mental Health and Addiction, 2019
With the increasing popularity of new media, problems involving its excessive use have emerged. The main aim of the study was to analyze the associations between Facebook intrusion, Internet addiction, self-esteem, and life satisfaction in Italy and the ...
Agata Błachnio, A. Przepiórka, M. Benvenuti, E. Mazzoni, Gwendolyn Seidman   +4 more
semanticscholar   +1 more source

Evaluation of the Reasons of Drug abuse in Women in Bushehr: A Qualitative Study

Journal of Qualitative Research in Health Sciences, 2019
Introduction: Drug addiction has always been considered as one of the most pervasive social problems. Although the risk of drug addiction is high in men, but this risk has been increased in women as well.
Fatemeh Akbarizadeh, Saharnaz Nejat, Ahmad Hajebi, Faezeh Jahanpour   +3 more
doaj  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Dynamical Analysis of Modified Mathematical Model of Social Media Addiction

Cauchy: Jurnal Matematika Murni dan Aplikasi
In this study, there is no division between addiction in the mild and severe stages. Therefore, it is necessary to divide the stages of addiction because the healing is clearly different.
Juhari Juhari, Zulfa Akfi Fikrina, Evawati Alisah, Imam Sujarwo   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source