Results 181 to 190 of about 45,221,204 (354)

The European Lead Extraction ConTRolled (ELECTRa) study: a European Heart Rhythm Association (EHRA) Registry of Transvenous Lead Extraction Outcomes

European Heart Journal, 2017
M. Bongiorni, C. Kennergren, C. Butter, J. Deharo, A. Kutarski, C. Rinaldi, Simone L Romano, A. Maggioni, M. Andarala, A. Auricchio, K. Kuck, C. Blomström-Lundqvist   +11 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Act in time: primary health care professionals', internal facilitators', and managers' experiences of working health-promotively after a 12-month implementation intervention: a qualitative study using normalization process theory. [PDF]

BMC Prim Care
Karin B, Ylva N, Maria HN, Lars W, Emma NS.   +4 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Implementing quality improvement in vascular services: a qualitative study. [PDF]

BMJ Open Qual
Birmpili P, Atkins E, Boyle JR, Chetter I, Cromwell DA, Glidewell L, Sheard L.   +6 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Drug-resistant TB treatment outcomes and factors associated with discontinuation and LTFU in Germany: No1Lost study protocol. [PDF]

IJTLD Open
Gödecke M, Eberhardt F, Barten-Neiner G, Knipper M, Aepfelbach N, Häcker B, Bauer T, Gröschel MI, Otto-Knapp R.   +8 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluating the impact of a longitudinal mentorship intervention on the documentation of maternal vital signs in Blantyre district, Malawi. [PDF]

BMC Pregnancy Childbirth
Mitchell A, Mwale NN, Simwinga L, Jana O, Rouse M, Baltzell K, Blair AH.   +6 more
europepmc   +1 more source