Results 141 to 150 of about 5,333,553 (268)

The Claims Data Learning & Enhancing for Algorithm Refinement (CLEAR) Study: Overview of the Study Design and Baseline Profile. [PDF]

J Epidemiol
Fukuda H, Maeda M, Ishiguro C.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

PCORnet®: An Infrastructure Supporting Innovation in Clinical Study Design. [PDF]

Med Care
Hernandez AF, Shenkman E, McTigue K, Kepler L, Cohen LW, Jolles MP, Rothman RL, Block JP, Carton TW, Tobin J, Priest EL, Evans C, Heintzman J, Williams DA.   +13 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Hokuriku-plus Heart Failure Registry Study　- Rationale and Study Design. [PDF]

Circ Rep
Takeji Y, Shimojima M, Nomura A, Noguchi M, Kamiya T, Ohira M, Hirai T, Mori M, Goten C, Okada H, Kusayama T, Yoshida S, Mori M, Tada H, Takashima SI, Kato T, Sakata K, Hayashi K, Fujino N, Takahashi I, Takahara S, Sugimoto S, Ohtani K, Yasuda T, Takeda Y, Yamamoto K, Kato C, Saeki T, Namura M, Yoshida T, Saito S, Usui S, Takamura M.   +32 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Study design considerations in clinical trials testing transcutaneous stimulation for spinal cord injury. [PDF]

Spinal Cord
Guest J, Moritz C.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Exosome diagnostics beyond the hype: why study design still matters. [PDF]

Int J Surg
Wang Z, Liu Q, Deng W.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source