Results 151 to 160 of about 45,092,884 (254)

Immune Mechanisms and Translational Study Design in Viral Vaccine Development. [PDF]

Int J Mol Sci
Lim S, Martina B.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Probiotic Human Study Design and Reporting (PRODARE): Recommendations to Improve Research Practice. [PDF]

Adv Nutr
Szajewska H, Benninga M, Chatonidi G, Costabile A, Lane J, van Loo-Bouwman CA, Mersh C, Morales PS, Walton G, Collado MC, Francavilla R, Fulling C, Holbech Jensen BA, Pascual DP, Ross PR, van den Akker CH, Vandenplas Y, Vidra N, Ouwehand AC.   +18 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A verbal and social autopsy study to improve estimates of mortality determinants in Pakistan: study design and methods. [PDF]

J Glob Health
Chauhadry IA, Soofi SB, Habib MA, Rizvi A, Khan A, Naqvi K, Kalter HD, Black RE, Bhutta ZA.   +8 more
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Study design and results of the Wave VI Add Health Cognitive Assessment, Physical, and Sensory Function (Add CAPS) protocol. [PDF]

J Gerontol B Psychol Sci Soc Sci
Aiello AE, Stebbins RC, Parker CNB, Rob FI, Martin CL, Rojas NB, Bennett DA, Manly JJ, Plassman BL, Reed NS, Myers CA, Batsis JA, Hummer RA.   +12 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Mindfulness and resource-sensitive design : a literature overview and an agenda for research

21st International Conference on Engineering Design (ICED 17), Vancouver, Canada, 21-25 August 2017202403 bckwVersion of RecordSelf-fundedPublishedVoR ...
de Bont, C, Chan, WMH
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