Results 151 to 160 of about 7,683,063 (318)

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

open access: yesFEBS Open Bio
Triple‐negative breast cancer (TNBC) is the most aggressive type of breast cancer, for which targeted treatment is currently lacking. Carbonic anhydrase IX (CAIX) is a known cancer target due to its selective overexpression in hypoxia, a hallmark of many
Zane Kalniņa   +13 more
doaj   +1 more source

Facebook as a Boundary Object in Industrial Design Studio. A SoTL Study

open access: yes, 2017
We introduced Facebook groups as instructional tools in our industrial design studio courses. One of us experienced the effects of Facebook on freshmen while the other examined it with sophomores and juniors.
İlhan, Işıl Oygür   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Human-Centered Design in Interior Design Education Last 20 Years: A Keyword Network Analysis and Visualization

open access: yes, 2021
Abundant research topics have been focused on social and individual needs as well as health and safety issues in the discipline of ID (Bhattacharjee & Lazo-Flores, 2016).
Park, Hye Jeong   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Modular product design and customization [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityThe paper deals with modular design architecture and its capabilities for easy and fast customization in products. The basic principles of modularity are mentioned and the most known methodologies and tools for modular
Chryssolouris, G., Pandremenos, J.
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The First International eDNA Workshop in Hong Kong: A beginner's guide for the next‐generation eDNA researcher

open access: yesEnvironmental DNA
The field of environmental DNA (eDNA) has rapidly advanced in recent years, providing a non‐invasive and time‐saving method for assessing biodiversity. The First International Environmental DNA (eDNA) Workshop in Hong Kong was held from 16 to 27 October ...
Mathew Seymour   +18 more
doaj   +1 more source

運用擴增實境於展示包裝設計之研究; The Study of Augmented Reality Technologies for Package Design

open access: yes, 2013
[[abstract]]包裝設計為商業產品設計中最專業的一環,而外型品質的發展與控制則為產品設計最重要的工作之一,包裝設計製作過程中經常依賴不同的設計媒材,如2D電腦繪圖軟體模擬圖呈現精確外觀但缺乏真實感,而初稿草圖則具真實感缺乏精細的尺度,兩者皆為包裝製作過程不可或缺的媒材。倘若設計師與客戶要討論包裝產品內容或細節,必須面對面的進行溝通,因此這是非常耗費人力與時間成本。經由擴增實境技術,將包裝的圖像符號加以分析辨識,透過3D虛擬圖像呈現,以協助設計師與客戶在遠地進行展示包裝產品,以降低人力與時間成本 ...
Chiu, Chao-Jong;Lai, Shu- Ling;Hsieh, Min-Chai
core  

A CMC-Based Design Communication for Collaborative Design Projects [PDF]

open access: yes, 2010
[[abstract]]Design processes in a traditional design project mainly rely on the designer’s personal skills such as drawing, presentation and prototyping capability.
HUNG-WEN HSU;HSIEN-JUNG WU;HSING-CHUNG KAO
core  

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