Results 161 to 170 of about 14,586,279 (354)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Learning Health SystemsBackground The Learning Health System (LHS) framework is designed to enhance healthcare by systematically integrating internal data and external evidence to promote quality, safety, and efficiency, aligning science, informatics, incentives, and culture ...
Michael R. Cauley +8 more
doaj +1 more source
Design study of an entry probe spectro-reflectometer [PDF]
A wind tunnel was built to simulate the rapid movement of an entry probe through the Jupiter atmosphere. Wind speeds range from 1 to 50 meters per second in a closed system.
Fink, U., Sill, G. T.
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Titanium-doped sapphire laser research and design study [PDF]
Three main topics were considered in this study: the fundamental laser parameters of titanium-doped sapphire, characterization of commercially grown material, and design of a tunable, narrow-linewidth laser.
Moulton, Peter F.
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Initial MPTS study results: Design considerations and issues [PDF]
One of the key issues identified during investigations of microwave power transmission systems from 1965 to 1976 was the need to assure that the billions of diodes on ground-based rectennas are sufficiently reliable to support long life times of ...
Maynard, O. E.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Design study for a magnetically supported reaction wheel [PDF]
Results are described of a study program in which the characteristics of a magnetically supported reaction wheel are defined. Tradeoff analyses are presented for the principal components, which are then combined in several reaction wheel design concepts.
Dendy, J., Sabnis, A., Stocking, G.
core +1 more source