Results 71 to 80 of about 45,271,957 (321)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

S3 Pupils' Career Aspirations and Views on Language Learning [PDF]

, 2007
In May 2005, the Scottish Centre for Language Teaching and Research (SCILT) undertook a government-funded nationwide survey of approximately 1500 pupils in the S3 cohort of Scottish secondary schools.
Doughty, Hannah, McPake, Joanna, Scottish Executive Education Department (Funder)   +2 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

INTERCULTURAL COMPETENCES AND INTERCULTURAL DIALOGUE. CASE STUDY ON BUCHAREST UNIVERSITY OF ECONOMICS [PDF]

The paper debates the topics of intercultural competences and intercultural dialogue. The main research whose results are being disseminated through this paper are part of a national research project, "Equality of chances and intercultural dialogue ...
DARABANT MARIA, IVANOVICI MINA, NEAGU-TROCMAER ANA-MARIA, SUCIU MARTA-CHRISTINA   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

COMMUNICATION: FUNCTIONS OF COMMUNICATION FROM THE PERSPECTIVE OF STUDYING FOREIGN LANGUAGES

Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2019
COMUNICAREA: FUNCȚIILE COMUNICĂRII DIN PERSPECTIVA STUDIERII LIMBILOR STRĂINE În articol este abordată problema comunicării ca fenomen social, accentul fiind pus pe analiza funcțiilor comunicării, pe competențele de comunicare în limbile străine din ...
USM ADMIN
doaj  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intercultural Communicative Competence and Employability in the Languages Curriculum at the Open University UK [PDF]

, 2017
In recent years, higher education in Great Britain has undergone considerable change, most markedly the increase in fees from about £9,000 for a BA degree to £27,000 in 2012 in England.
Baumann, Uwe, Vialleton, Elodie
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

СЛАВЯН ТІЛДЕРІНДЕГІ ТҮРКИЗМДЕРДІҢ ЗЕРТТЕЛУ ТАРИХЫ

Әл-Фараби Атындағы Қазақ Ұлттық Университеті хабаршы шығыстану сериясы, 2016
В этой статье рассматривается вопросы изучения тюркизмов в славянских языках, пути проникновения, проблемы взаимовлияния и взаимообогащения контак- тирования языков.
Ұ. Т. Алжанбаева
doaj