Results 271 to 280 of about 177,707 (371)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

My Husband, His Stunning Dermaflorescence

, 2015
Kim Hagerich
openalex   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Rainbow trout welfare: comparing stunning methods in winter and summer. [PDF]

Fish Physiol Biochem
González-Garoz R, Cabezas A, Fernández-Muela M, Martínez Villalba A, González de Chávarri E, Villarroel M, De la Llave-Propín Á, De la Fuente J, Bermejo-Poza R, Díaz MT.   +9 more
europepmc   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source

Ischaemic preconditioning regulates cardiac transcriptome via DNA methylation conferring cardio-protection from ischaemic reperfusion injury. [PDF]

Eur Heart J Open
Khan AW, Hussain S, Elmahdy A, Kakaei Y, Espinosa AS, Jha A, Omerovic E, Aziz M, Maxwell S, Jandeleit-Dahm KAM, Redfors B.   +10 more
europepmc   +1 more source

INSENSIBILIZAÇÃO DE BOVINOS ABATIDOS NO PANTANAL SUL MATOGROSSENSE E OCORRÊNCIA DE LESÕES EM CARCAÇAS STUNNING OF BEEF CATTLE SLAUGHTERED IN THE PANTANAL OF MATO GROSSO DO SUL STATE AND OCCURRENCE OF CARCASS BRUISING

, 2008
Heraldo César Gonçalves, Roberto Aguilar Machado Santos Silva, Roberto de Oliveira Roça, Ernani Nery de Andrade   +3 more
openalex   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Coronary Artery Disease and Intradialytic Myocardial Ischemia in Hemodialysis: An Exploratory Study Using Intradialytic Imaging. [PDF]

Kidney Med
Hur L, Islam A, Penny JD, Dorie J, McIntyre CW.   +4 more
europepmc   +1 more source

Rhaponticoides nuriae (Asteraceae), a stunning new species from Morocco

Abdelmonaim Homrani Bakali, Alfonso Susanna   +1 more
openalex   +1 more source