Results 101 to 110 of about 251,162 (278)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Acute and Sub-acute Toxicity Studies of the Aqueous Leaf Extract of Lippia multiflora from the Bélier Region (Côte d’Ivoire) [PDF]

, 2020
Fulgence Yapo Allo, Brou André Konan, Souleymane Méité, Jacques Yao Datté   +3 more
openalex   +1 more source

Solvent‐Free Bonding Mechanisms and Microstructure Engineering in Dry Electrode Technology for Lithium‐Ion Batteries

Advanced Functional Materials, EarlyView.
Dry electrode technology revolutionizes battery manufacturing by eliminating toxic solvents and energy‐intensive drying. This work details two promising techniques: dry spray deposition and polymer fibrillation. How their unique solvent‐free bonding mechanisms create uniform microstructures for thicker, denser electrodes, boosting energy density and ...
Yuhao Liang, Hao Long, Zimo Huang, Ting He, Xueming Chen, Meng Li, Hao Chen, Shanqing Zhang   +7 more
wiley   +1 more source

L-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in mice. [PDF]

Arh Hig Rada Toksikol, 2023
Bakan B, Oltulu F, Yıldırım Y, Yavaşoğlu A, Akgöl S, Karabay Yavaşoğlu NÜ.   +5 more
europepmc   +1 more source

Gender effects on cytidine analogue metabolism and myelodysplastic syndrome treatment outcomes [PDF]

, 2012
In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine ...
Ania Jankowska, Jaroslaw Maciejewski, Joseph Covey, Kenneth Chan, Kory Engelke, Mikkael Sekeres, Pramod Terse, Quteba Ebrahem, Ramon Tiu, Reda Mahfouz, Tomas Radivoyevitch, Yogen Saunthararajah, Yonghua Ling, Zhenbo Hu   +13 more
core   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Evaluation of acute and sub-acute toxicity profile of 5-methylcoumarin-4β-glucoside in mice. [PDF]

Toxicol Rep, 2022
Abubakar B, Alhassan AM, Malami I, Usman D, Uthman YA, Adeshina KA, Olatubosun MO, Imam MU.   +7 more
europepmc   +1 more source

Assessment of acute and sub-acute toxicity of olive pomace in female Wistar rats

, 2022
Zouleykha Badi, Baya Guermouche, Nahida Haddam, N. Belyagoubi, Karima Rouigueb, H. Benzerjeb, Majda Dali-Sahi, Youssouf Kachekouche, Hafida Merzouk   +8 more
openalex   +2 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Sub-acute toxicity study on hydromethanolic leaves extract of Combretum hypopilinum (Combretaceae) Diels in Wistar rats. [PDF]

Toxicol Res, 2022
Ahmad MH, Zezi AU, Anafi SB, Alshargi OY, Mohammed M, Mustapha S, Bala AA, Muhammad S, Julde SM, Wada AS, Jatau AI.   +10 more
europepmc   +1 more source