Results 1 to 10 of about 659 (67)

Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats

Toxins, 2019
Microcystin-LR (MCLR) is a hepatotoxic cyanotoxin reported to cause a phenotype similar to nonalcoholic steatohepatitis (NASH). NASH is a common progressive liver disease that advances in severity due to exogenous stressors such as poor diet and toxicant
Tarana Arman, Katherine D. Lynch, Michelle L. Montonye, Michael Goedken, John D. Clarke   +4 more
doaj   +3 more sources

Acute and sub-chronic toxicity study of novel polyherbal formulation in non-alcoholic fatty liver using Wistar rats

Future Science OA
Aim: This study assessed the acute and sub-chronic toxicity of a novel polyherbal formulation tablet in Wistar rats Materials & methods: Acute toxicity and sub-chronic toxicity was assessed following OECD (Organisation for the Economic Co-operation and ...
Anuragh Singh, K Ilango
doaj   +3 more sources

Dose and time-dependent sub-chronic toxicity study of hydroethanolic leaf extract of Flabellaria paniculata Cav. (Malpighiaceae) in rodents

Frontiers in Pharmacology, 2014
Flabellaria paniculata Cav. (Malpighiaceae) is a climbing shrub, the preparations of which are used in the treatment of wounds and ulcers in Nigeria and Ghana. This study investigated the sub-chronic toxicity profile of the hydroethanolic leaf extract of
Abidemi James Akindele, Adejuwon Adewale Adeneye, Oluwole Saidi Salau, Margaret Oluwatoyin Sofidiya, Adokiye Senibo Benebo   +4 more
doaj   +3 more sources

Acute and sub-chronic oral toxicity study of purple sweet potato (Ipomoea batatas [L.] Lam) yogurt in mice (Mus musculus) [PDF]

Veterinary World, 2022
Background and Aim: Food safety is an important aspect to be evaluated in preventing any potentially harmful side effects of food product such as yogurt. The purple sweet potato yogurt product was developed to combine the benefits of probiotic activities
Astrid Feinisa Khairani, Yunisa Pamela, Nandina Oktavia, Achadiyani Achadiyani, M. Yusuf Adipraja, Prita Yasri Zhafira, Widad Aghnia Shalannandia, Nur Atik   +7 more
doaj   +1 more source

Sub-acute and sub-chronic toxicity assessment of the antimicrobial peptide Dermaseptin B2 on biochemical, haematological and histopathological parameters in BALB/c mice and Albino Wistar rats

Heliyon, 2022
Background: Dermaseptins (Drs) are peptides found in the skin secretions of a variety of Hylid frogs, particularly those belonging to the Agalychnis and Phyllomedusa families. Dermaseptin B2 (Drs B2), an amphipathic, α-helical polypeptide was reported as
Ahmed A. Abdille, Shedrack Reuben Kitimu, Mark M. Ndubi, Josephine Kimani, Esther N. Maina, Wallace Bulimo, Yahaya Gavamukulya, Fred Wamunyokoli   +7 more
doaj   +1 more source

Acute and Sub-Chronic Toxicity Study of 1-(2, 5-Dihidroxyphenil)-3- Pyridine-2-Il-Propenone In Adult Female Mice

Indonesian Journal of Pharmacy, 2021
This research aimed to evaluate the toxicity of 1-(2, 5-dihidroxyphenil)-3-pyridine-2-il-propenone (DPP) after 24 hours and 90-day administration in female mice. Acute toxicity test was performed using the OECD 423 method, and DPP was administered once a
Ika Puspitasari, Ratna Asmah Susidarti, Arief Nurrochmad, Pridiyanto Pridiyanto, Devie Amalia Utami, Pipit Febrian, Thoriq Ziyad   +6 more
doaj   +1 more source

Sub-chronic toxicity study of green peas protein hydrolysate in rats

Toxicology Reports, 2022
Despite green peas protein hydrolysate benefits, very few studies have described the potential toxicity. The acute oral toxicity of green peas protein which hydrolyzed by bromelain at a single dose of 5000 mg/kg BW has been evaluated in Swiss Webster ...
Meilinah Hidayat, Sijani Prahastuti, Anggie S. Rakasiwi, Sipra Prisilia, Khomaini Hasan   +4 more
doaj   +1 more source

CLONAZEPAM INDUCED SUB CHRONIC HEPATORENAL TOXICITY IN RATS AND THE PROTECTIVE ROLE OF ALPHA-TOCOPHEROL [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2023
Background: Clonazepam (CZP) is an antiepileptic drug approved in 1976 by Food and Drug Administration (FDA) for treatment of various types of seizures, Clonazepam has a high potential for abuse, as well as tolerance, physical dependence, and ultimately ...
nada Abdel-raof, Mahmoud Khattab, Fatma Abdel Maksoud, Maha Emad Eldein, Ahmed Elshatory, Walaa Awad, Mohammad El-Kattan   +6 more
doaj   +1 more source

Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar rats

Toxicology Reports, 2020
Background: Combretum micranthum (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inflammation, malaria and liver ailments.
Mabozou Kpemissi, Kossi Metowogo, Mamatchi Melila, Veeresh P. Veerapur, Mihai Negru, Marian Taulescu, Adrian-Valentin Potârniche, Doddamavattur Shivalingaiah Suhas, Tumbadi Adinarayanashetty Puneeth, Sachidananda Vijayakumar, Kwashie Eklu-Gadegbeku, Kodjo Aklikokou   +11 more
doaj   +1 more source

Hepatoprotective activity of Picrorhiza kurroa and Berberis lycium is mediated by inhibition of COX-2 and TGF-β expression in lantadenes-induced sub-chronic toxicity in guinea pigs

Phytomedicine Plus, 2022
Background: The toxicity of Lantana camara weed is common in grazing livestock throughout the world. Specific treatment for the toxicity is lacking. However, herbal plants could be investigated for their effectiveness in inhibiting hepatic damage caused ...
Punam Soren, Rinku Sharma, Gorakh Mal, Bikram Singh, Pawan Kumar, Rajendra Damu Patil, Birbal Singh   +6 more
doaj   +1 more source