Results 41 to 50 of about 780 (181)

Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

Food Safety and Health
Bletilla formosana (Hayata) Schltr. is an important economic medicinal and edible plant in China. Its tubers (BFTs) are traditionally consumed as a beverage and canned foods for promoting human health.
Yongchao Wang, Jian Zhang, Tianrui Zhao, Jianxin Cao, Afsar Khan, Zhengxuan Wang, Yaping Liu, Guiguang Cheng   +7 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evaluation of Albizia lebbeck and Curcuma longa Extracts on Gastrointestinal Motility, Safety, and Hematological Parameters: A Sub-Chronic Toxicity and Pharmacological Study [PDF]

Asia Pacific Journal of Medical Toxicology
Background: Gastrointestinal disorders are prevalent worldwide, necessitating effective and safe therapeutic options. The use of herbal medicine dates back thousands of years, with various cultures employing plants to treat ailments.
Bushirat Fagbohun, Hassan Adewuyi, Maryam Musa, Ojochenemi Unuata, Ochonung Ogar, Agor Achi, Usman Mohammed, Jaiyeola Olukayode   +7 more
doaj   +1 more source

Physiological and Behavioral Effects of SiO₂ Nanoparticle Ingestion on Daphnia magna

Micromachines, 2021
The increasingly widespread use of engineered nanoparticles in medical, industrial, and food applications has raised concerns regarding their potential toxicity to humans and the environment.
Youngsam Kim, Afshin Samadi, Eun Heui Gwag, Jayoung Park, Minjeong Kwak, Jihoon Park, Tae Geol Lee, Young Jun Kim   +7 more
doaj   +1 more source

Thallium Induced Sub-chronic Toxicity Profile in Wistar Rats

Indian Journal of Veterinary Sciences & Biotechnology, 2022
Thallium (Tl) is one of the most toxic heavy metals affecting both humans and animals, yet is one of the least studied for its toxicological effects. A total of 40 male Wistar rats were randomly divided into four Groups with 10 rats in each  Group. Group I received distilled water only and served as a control.
Parvez I. Sindhi, Samir H. Raval, Ratn Deep Singh, Rohit S. Parmar, Jasmi G. Patel, Bakor J. Patel, Dilip V. Joshi   +6 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Toxicological Effects of Leachates Extracted from Photocatalytic Concrete Blocks with Nano-TiO₂ on Daphnia magna

Nanomaterials
The incorporation of titanium dioxide nanoparticles into concrete blocks for paving adds photocatalytic functionality to the cementitious matrix, providing self-cleaning and pollutant-degrading properties.
Fernanda Facin, João Victor Staub de Melo, Rodrigo Costa Puerari, William Gerson Matias   +3 more
doaj   +1 more source

Toxicological evaluation of subchronic use of pioglitazone in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Pioglitazone (Actos) is one of the most controversial recent oral antidiabetic drugs. It was originally authorized in the European Union in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002 ...
Said Said Elshama, Ayman El-Meghawry El-Kenawy, Hosam-Eldin Hussein Osman   +2 more
doaj  

Acute and sub-chronic toxicity assessment and evaluation of the gastro-protective activity of polyherbal formulation “Mystomate4®” against gastric ulcer in experimental laboratory animal

Clinical Phytoscience, 2022
Background Ulcer remains a health challenge worldwide with antibiotics and proton pump inhibitors as major management therapy. The study investigated the acute, sub-chronic toxicity and gastrointestinal protective activity of a polyherbal formulation ...
Funmileyi Olubajo Awobajo, Margaret Oluwatoyin Sofidiya, Olayinka Taiwo Asekun, Babafemi Oluwole Familoni   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source