Results 61 to 70 of about 780 (181)

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Toxicity assessment of Cucurbita pepo cv Dayangua and its effects on gut microbiota in mice

BMC Complementary Medicine and Therapies
Background Cucurbita pepo cv Dayangua (CPD) is an edible plant with diverse pharmacological properties. The current research on CPD has primarily focused on initial investigations of its chemical composition and pharmacological effects, and no ...
Huan Zhang, Yazhou Zhou, Zhiyuan Pan, Bikun Wang, Lei Yang, Nan Zhang, Baiyi Chen, Xiaona Wang, Zhiguang Jian, Likun Wang, Hui Ling, Xiaoming Qin, Zhelin Zhang, Teng Liu, Aiping Zheng, Yafang Tan, Yujing Bi, Ruifu Yang   +17 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Sub-chronic toxicity of chemically synthesized CuO-NPs in albino mice

Biomarkers
Objectives: The current study explores the synthesis, characterization and toxicity of copper oxides (CuO-NPs) in albino mice. Methods: NPs were synthesized and albino mice were exposed to these nps orally for 30 days. Results: The nanoparticles exhibited a porous, rough-surfaced, spherical morphology; XRD confirmed their crystallinity, while FTIR ...
Muhammad Waseem Aslam, Ali Umar, Muhammad Saleem Khan, Muhammad Wajid, Sabeen Sabri, Misbah Ullah Khan   +5 more
openaire   +2 more sources

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Sub Chronic Toxicity Study of Coumacines

Pharmacognosy Journal, 2023
Wejdan Al-Shakarchi, Yasir Saber, Marwan M Merkhan, Yasser Fakri Mustafa   +3 more
openaire   +1 more source

Sub chronic toxicity studies of lactulose in rats.

Indian journal of experimental biology, 2001
Lactulose has profound health benefits by way of increasing bifidobacterial flora in the intestine of infants thereby protecting them against enteric infection, constipation and systemic encephalopathy. In the present study to assess the sub chronic toxicity of lactulose syrup, the rats were fed on a basal feed supplemented with lactulose syrup at 0.5,
V, Baskaran, K N, Murthy, , Mahadevamma, S, Vishwanatha, B R, Lokesh   +4 more
openaire   +1 more source

Karl Popper and the Mechanisms of Hydrogen Embrittlement

Advanced Engineering Materials, EarlyView.
Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

Acute and sub-chronic toxicological evaluation of ethanol extract of Solanum trilobatum Linn. [PDF]

Research Journal of Pharmacognosy, 2018
Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear.
S. Parasuraman*, L. Yu Ren, B. Lau Chik Chuon, S. Wong Kah Yee   +3 more
doaj