Results 181 to 190 of about 93,383 (228)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Acute and Sub-Acute Toxicity Evaluation of the Methanolic Extract of Alstonia scholaris Stem Bark. [PDF]

Med Sci (Basel), 2016
Bello I, Bakkouri AS, Tabana YM, Al-Hindi B, Al-Mansoub MA, Mahmud R, Asmawi MZ.   +6 more
europepmc   +1 more source

Reply to Comment on “Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values”

ALTEX, 2018
Andrea, Gissi, Kimmo, Louekari, Laurence, Hoffstadt, Norbert, Bornatowicz, Alberto M, Aparicio   +4 more
openaire   +3 more sources

Functional Metal Complexes for Solar–Light‐Driven Energy Conversion

Advanced Materials, EarlyView.
This review provides an exhaustive summary of the recent advancements of functional metal complexes in solar‐to‐electrical, ‐chemical, and ‐thermal energy conversion, comprising material categories, design strategies, underlying principles of operation, and identified improvement of performances.
Yanyan Qin, Dou Luo, Miao Zhang, Wai‐Yeung Wong   +3 more
wiley   +1 more source

Diverse Cation Exchange in Layered Titanate Nanostructures for Tailored Catalysis

Advanced Materials, EarlyView.
H+(H3O+)‐intercalated layered titanate enables stable intercalation of 42 single‐metal and multication combinations. Alkali‐metal intercalation tunes Rh charge density, yielding an efficient propylene hydroformylation catalyst. These results establish a generalizable intercalation platform for rational catalyst design and provide a library supporting ...
Hyoseok Kim, Daewon Oh, Miyeon Kim, Taein Lee, Sihyeon Baek, Wonsik Jang, Jong‐Seong Bae, Jihun Kim, Jongkyoung Kim, Taeheon Kim, Changhun Hur, Sinmyung Yoon, Hu Young Jeong, Jeong Woo Han, Kwangjin An, Seungho Cho   +15 more
wiley   +1 more source

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Two‐Photon 3D Printing of Functional Microstructures Inside Living Cells

Advanced Materials, EarlyView.
This study demonstrates 3D printing inside living cells by using two‐photon photo‐lithography. A bio‐compatible photoresist is injected into cells and selectively polymerized with a femtosecond laser, creating custom‐shaped intracellular structures with submicron resolution.
Maruša Mur, Aljaž Kavčič, Uroš Jagodič, Rok Podlipec, Matjaž Humar   +4 more
wiley   +1 more source

Deployable 3D‐Printed Vascular Stent with Surface‐Catalysed Endogenous Nitric Oxide Generation

Advanced Materials, EarlyView.
A deployable 3D‐printed vascular stent was fabricated with surface‐catalyzed endogenous nitric oxide generation, representing a promising new direction for stent development. The stent can be remotely controlled by magnetic force in its compressed state and fully deployed at the target site using an untethered heat source, potentially eliminating the ...
Kun Zhou, Zifei Han, Kang Lin, Di Wu, Siti Nur Asyura Adzlan, Qingqing Fan, Christina Cortez‐Jugo, Rona Chandrawati, Cyrille Boyer   +8 more
wiley   +1 more source

Photochemical Fuel Carrier Molecules for Robotic Embodied Energy

Advanced Materials, EarlyView.
We designed a novel fuel carrier photoresponsive molecule for on‐demand energy storage and release. Carrier molecules undergo bond scission under UV light to release chemical fuel and locally generate propulsive Marangoni flows. We demonstrate this photochemical embodied energy strategy in small‐scale robots and active matter systems, enabling ...
Chuqi Huang, Songah Jeong, Ji Woo Kim, Kanyarat Mantala, Zenghao Zhang, Hyungwoo Kim, Abdon Pena‐Francesch   +6 more
wiley   +1 more source