Results 91 to 100 of about 129,421 (342)

Mono‐ and Bivalent Poly(iso‐butylene)‐Alanines for Drug‐Delivery of Nimodipine and Triamcinolone Acetonide

Macromolecular Rapid Communications, EarlyView.
Mono‐ and bivalent‐, alanine‐modified poly‐iso‐butylenes, folding into beta‐sheets, were prepared by living carbocationic polymerization and subsequent endgroup modification. These PIB‐conjugates are useful as solid polymers for the drug release of triamcinolone and nimodipine. ABSTRACT Poly‐iso‐butylene (PIB) is a well known biocompatible polymer with
Philipp S. Hilgeroth, Julius F. Butter, Wolfgang H. Binder   +2 more
wiley   +1 more source

Plasma Soluble Human Elastin Fragments as an Intra-Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm [PDF]

, 2018
Background—Fragmentation of the tunica media is a hallmark of intracranial aneurysm formation, often leading to aneurysmal progression and subsequent rupture.
Allan, Lauren, Hasan, David M., Hudson, Joseph, Ishii, Daizo, Jabbour, Pascal, Nakagawa, Daichi, Ortega-Gutierrez, Santiago, Samaniego, Edgar A., Teferi, Nahom, Zanaty, Mario   +9 more
core   +1 more source

Investigation of the Determinants of Disease Severity in Patients with Idiopathic Normal Pressure Hydrocephalus

Movement Disorders Clinical Practice, EarlyView.
Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder, Ahmet Gunaydin, Nursu Erdogan, Selcuk Comoglu   +3 more
wiley   +1 more source

Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage

Neural Regeneration Research
Neuronal cell death is a common outcome of multiple pathophysiological processes and a key factor in neurological dysfunction after subarachnoid hemorrhage. Neuronal ferroptosis in particular plays an important role in early brain injury.
Peng Lu, Fan Zhang, Lei Yang, Yijing He, Xi Kong, Kecheng Guo, Yuke Xie, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng   +10 more
doaj   +1 more source

Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]

, 2016
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois, Diringer, Michael N, Etminan, Nima, Faleck, Herbert J, Hanggi, Daniel, Hoh, Brian L, Macdonald, R. Loch, Mayer, Stephen A, Mocco, J, Newton Investigators,, Steiger, Hans Jakob   +10 more
core   +3 more sources

Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model

Obesity, EarlyView.
ABSTRACT Objective This study aimed to investigate the associations of body roundness index (BRI) with cardiometabolic disease (CMD), cardiometabolic multimorbidity (CMM), and all‐cause mortality, while evaluating its impact across different stages of CMM progression. Methods In this prospective cohort study, 87,902 participants from the Kailuan cohort
Xi Cai, Yicheng Liao, Xuemei Yang, Yajing Liang, Jiajia Ma, Ruiyue Liu, Xinran Wen, Wenli Yin, Shuohua Chen, Guodong Wang, Na Li, Shouling Wu, Liufu Cui   +12 more
wiley   +1 more source

Management of Subarachnoid Hemorrhage and Complications: Review

Ankara Üniversitesi Tıp Fakültesi Mecmuas, 2011
Subarachnoid hemorrhage is a pathologic condition that exists when the blood spread through the subarachnoid space and it is an important cause of morbidity and mortality in middle-age group.
Mevci Özdemir, Melih Bozkurt, Gökmen Kahiloğulları, Hasan Çaglar Uğur, Nihat Egemen   +4 more
doaj   +1 more source

Brain tumors induced in rats by human adenovirus type 12 [PDF]

, 1974
Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu　strains were injected intracranially with human adenovirus type 12.　The incidence of intracranial tumors was 91% (30/33) in
Matsuo, Keisuke, Murao, Tsuyoshi, Ogawa, Katsuo, Ohmori, Hiroyuki, Sonobe, Hiroshi, Tsutsumi, Akira   +5 more
core   +1 more source

Overall outcome, functioning, and disability in older adults 3 to 14 years after traumatic brain injury

PM&R, EarlyView.
Abstract Background Epidemiological studies show an increasing incidence of traumatic brain injury (TBI) among people aged 65 years and older. Advances in neurointensive care have improved survival after TBI. There is a need for knowledge about long‐term outcome after TBI among older survivors of TBI.
Charlotta von Seth, Anders Lewén, Marianne Lannsjö, Per Enblad, Jan Lexell   +4 more
wiley   +1 more source

A Review of Neurogenic Stunned Myocardium. [PDF]

, 2017
Neurologic stunned myocardium (NSM) is a phenomenon where neurologic events give rise to cardiac abnormalities. Neurologic events like stroke and seizures cause sympathetic storm and autonomic dysregulation that result in myocardial injury.
Agrawal, Akanksha, Biso, Sylvia, Figueredo, Vincent M., Kishlyansky, Marina, Wongrakpanich, Supakanya, Yadlapati, Sujani   +5 more
core   +3 more sources