Results 91 to 100 of about 123,650 (327)

Investigation of the Determinants of Disease Severity in Patients with Idiopathic Normal Pressure Hydrocephalus

Movement Disorders Clinical Practice, EarlyView.
Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder, Ahmet Gunaydin, Nursu Erdogan, Selcuk Comoglu   +3 more
wiley   +1 more source

Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage

Neural Regeneration Research
Neuronal cell death is a common outcome of multiple pathophysiological processes and a key factor in neurological dysfunction after subarachnoid hemorrhage. Neuronal ferroptosis in particular plays an important role in early brain injury.
Peng Lu, Fan Zhang, Lei Yang, Yijing He, Xi Kong, Kecheng Guo, Yuke Xie, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng   +10 more
doaj   +1 more source

Plasma Soluble Human Elastin Fragments as an Intra-Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm [PDF]

, 2018
Background—Fragmentation of the tunica media is a hallmark of intracranial aneurysm formation, often leading to aneurysmal progression and subsequent rupture.
Allan, Lauren, Hasan, David M., Hudson, Joseph, Ishii, Daizo, Jabbour, Pascal, Nakagawa, Daichi, Ortega-Gutierrez, Santiago, Samaniego, Edgar A., Teferi, Nahom, Zanaty, Mario   +9 more
core   +1 more source

High-Flow Vascular Malformations in Children. [PDF]

, 2020
Children can have a variety of intracranial vascular anomalies ranging from small and incidental with no clinical consequences to complex lesions that can cause substantial neurologic deficits, heart failure, or profoundly affect development. In contrast
Abla, Adib A, Braunstein, Steve, Cooke, Daniel L, Fullerton, Heather J, Gupta, Nalin, Hetts, Steven W, Kim, Helen, Morshed, Ramin A, Winkler, Ethan A   +8 more
core  

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]

, 2016
BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki, Kanematsu, Yasuhisa, Kitazato, Keiko T, Korai, Masaaki, Matsushita, Nobuhisa, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Shimada, Kenji, Tada, Yoshiteru   +9 more
core   +2 more sources

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

Management of Subarachnoid Hemorrhage and Complications: Review

Ankara Üniversitesi Tıp Fakültesi Mecmuas, 2011
Subarachnoid hemorrhage is a pathologic condition that exists when the blood spread through the subarachnoid space and it is an important cause of morbidity and mortality in middle-age group.
Mevci Özdemir, Melih Bozkurt, Gökmen Kahiloğulları, Hasan Çaglar Uğur, Nihat Egemen   +4 more
doaj   +1 more source

Frontal Lobe and Psychopathy [PDF]

, 2015
This research paper presents an analysis of the functions of the frontal lobe and how damage to the frontal lobe correlates to psychopathy. Initially, it will look at how damage to the frontal lobe obstructs frontal lobe functions.
Germain, Shawna
core   +1 more source

Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]

, 2016
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois, Diringer, Michael N, Etminan, Nima, Faleck, Herbert J, Hanggi, Daniel, Hoh, Brian L, Macdonald, R. Loch, Mayer, Stephen A, Mocco, J, Newton Investigators,, Steiger, Hans Jakob   +10 more
core   +3 more sources

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Phytochemical Analysis, EarlyView.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source