Results 91 to 100 of about 36,100 (249)
Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum
Clinical Anatomy, EarlyView.ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery +4 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Bone grafting in equine medicine offers a promising contribution to treating orthopaedic developmental diseases and chondral, osteochondral and segmental bone defects. Among grafts, synthetic bone substitutes—alloplastics—show favourable biological properties addressing numerous limitations presented by autografts, xenografts and ...
Katarzyna Skierbiszewska +6 more
wiley +1 more source
Journal of Orthopaedic TranslationObjective: To investigate the role of osteoclast-derived apoptotic bodies (OC-ABs) in osteoarthritis (OA), specifically their impact on subchondral bone remodeling and disease progression, and to explore potential therapeutic strategies targeting OC-AB ...
Hongbo Ai +12 more
doaj +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Culture protocols need to yield 100 million equine synovial fluid (SF)‐derived mesenchymal stromal cells (SF‐MSCs) in around 3 weeks are needed, before these cells can be evaluated as agents of articular repair in clinical trials. Objectives To investigate mass culture of equine SF‐MSC culture protocols using nonwoven polyethylene ...
Miho Daniel Yoshitomi +5 more
wiley +1 more source
Review of articular cartilage repair techniques and their application in the horse
Equine Veterinary Journal, EarlyView.Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton +2 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor +7 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Proximal interphalangeal joint osteoarthritis (PIPJ OA) is a common cause of poor performance in the equine athlete; however, the supporting soft tissue structures surrounding the joint are seldom evaluated. Straight sesamoidean ligament injuries have been previously hypothesised to be concomitant with PIPJ OA; however, the ...
Charlotte K. Barton +3 more
wiley +1 more source
Exploration, EarlyView.Based on the interaction between the weakly cross‐linked disulfide bonds that break under stress and charge‐reversal messenger molecules, we herein achieved nanoparticle charge reversal under stress and constructed a stress‐responsive charge‐reversal hydrogel microsphere system using microfluidic technology.
Feng Lin +11 more
wiley +1 more source
Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling
Interdisciplinary Medicine, EarlyView.Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang +3 more
wiley +1 more source
Mapping Fatty Acid Composition in the Human Knee: Short‐Term Repeatability at 3T
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Alterations in periarticular lipid composition are implicated in musculoskeletal diseases, yet short‐term reliability of MRI‐based triglyceride composition mapping in the knee is not fully established. Purpose To evaluate 1‐week repeatability of proton‐density fat fraction (PDFF) and triglyceride fatty‐acid composition—saturated ...
Dimitri Martel +8 more
wiley +1 more source