Results 51 to 60 of about 36,100 (249)

Skeletal interoception in osteoarthritis

Bone Research
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism.
Dinglong Yang, Jiawen Xu, Ke Xu, Peng Xu
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Anti‐inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota

Animal Models and Experimental Medicine, EarlyView.
Transcutaneous electrical nerve stimulation (TENS) improved knee osteoarthritis (KOA) in rats by regulating interleukin‐1β (IL‐1β), IL‐6, and IL‐8 expressions and the bone morphogenetic protein 2 (BMP‐2)/transforming growth factor β (TGF‐β) signaling pathway.
Yan Sun, Tong Ma, Ran Chen, Lan Shen, Xun Tang, Zhiqiang Shen, Hongbin Zhao   +6 more
wiley   +1 more source

Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints

Scientific Reports, 2022
Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects both
Sara Ajami, Behzad Javaheri, Y.-M. Chang, Nimalan Maruthainar, Tahir Khan, James Donaldson, Andrew A. Pitsillides, Chaozong Liu   +7 more
doaj   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Integrating whole‐bone and regional analyses to understand human scapular growth

The Anatomical Record, EarlyView.
Abstract This study investigates ontogenetic changes in human scapular morphology using three‐dimensional geometric morphometrics with whole‐bone and region‐specific analyses. The aim is to evaluate whether the scapula follows a regular developmental pattern and whether its functionally distinct components, the scapular spine (SS) and glenoid fossa ...
Azahara Salazar‐Fernández, José Miguel Carretero, Laura Rodríguez, Rebeca García‐González   +3 more
wiley   +1 more source

Healing Integrity Determines Meniscal Extrusion After Isolated Medial Meniscus Posterior Root Repair in Knees With No Lower Limb Malalignment

Arthroscopy, EarlyView.
Purpose To investigate changes in meniscal extrusion and meniscal healing status following root repair, and the relationship between meniscal extrusion and healing conditions. Methods Patients who underwent isolated root repair between 2019 and 2023 and consented to undergo second‐look arthroscopy to evaluate their healing condition (1 year ...
Jin Seong Kim, Ui Jae Hwang, Chang Woo Woo, Choong Hyeok Choi, Kyu Sung Chung   +4 more
wiley   +1 more source

Bone sialoprotein—a new marker for subchondral bone

Osteoarthritis and Cartilage, 1999
THE exact role of the subchondral bony plate in osteoarthritis in man is unclear, since studies to date have been confined to spontaneous and induced experimental models in animals. Histologic material from man is rarely available and the microscopic anatomy cannot be studied in prospective studies.
openaire   +2 more sources

Female Patients Exhibit a Narrower Glenoid Rim and Lower Bone Density in the Anteroinferior Quadrant Compared With Male Patients

Arthroscopy, EarlyView.
Purpose The purpose of this study was to evaluate sex‐based differences in glenoid rim morphology and bone density relevant to arthroscopic Bankart repair. Methods This retrospective study assessed differences in glenoid rim morphology between sexes in patients with shoulder instability and uninjured control subjects who underwent a magnetic resonance ...
Willem Geuskens, Haider Ali Lakdawala, Maïté Jaspers, Tom Doyle, Damir Rasidovic, Olivier Verborgt, Oisin Flanagan, Eoghan Hurley, Hannan Mullett   +8 more
wiley   +1 more source