Results 101 to 110 of about 1,244,249 (241)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Note on Locally Inverse Semigroup Algebras
International Journal of Mathematics and Mathematical Sciences, 2008 Let R be a commutative ring and S a finite locally inverse semigroup. It is proved that the semigroup algebra R[S] is isomorphic to the direct product of Munn algebras ℳ(R[GJ],mJ,nJ;PJ) with J∈S/𝒥, where mJ is the number of ℛ-classes in J, nJ the
Xiaojiang Guo
doaj +1 more source
Virus Research, 2019 The lifecycle of avian leukosis virus subgroup J (ALV-J), a typical tumorigenic retrovirus, is highly dependent upon host cellular proteins. However, there have been few studies directed at uncovering the host proteins responsible for ALV-J replication, which could provide insights into new strategies for ALV-J prevention and control.
Yu, Pang +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Journal of Animal Science and Biotechnology, 2019 Background Previously, we showed that targeted disruption of viral receptor genes in avian leukosis virus (ALV) subgroups using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9))-based genome editing ...
Hong Jo Lee +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Extracta MathematicaeLet d ≥ 2. In this paper we prove that Id(ℓ, a) fills Rd face–to–face by translations. We prove that the symmetry group of Id(ℓ, a) contains the product of cyclic groups Cd × C2 as a subgroup.
María Jesús de la Puente
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Volume of complete anti-de Sitter 3-manifolds
, 2015 Up to a finite cover, closed anti-de Sitter $3$-manifolds are quotients of $\mathrm{SO}_0(2,1)$ by a discrete subgroup of $\mathrm{SO}_0(2,1) \times \mathrm{SO}_0(2,1)$ of the form \[j\times \rho(\Gamma)~,\] where $\Gamma$ is the fundamental group of a ...
Tholozan, Nicolas
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source