The tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication [PDF]
Virulence, 2021 Avian leukosis virus subgroup J (ALV-J) generally induces hemangioma, myeloid leukosis, and immunosuppression in chickens, causing significant poultry industry economic losses worldwide. The unusual env gene of ALV-J, with low homology to other subgroups
Aijian Qin, Jing Xie, Quan Xie
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SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and neoplastic diseases in poultry. Cytokine signal-transduction inhibitor molecule 3 (SOCS3) is an important negative regulator of the JAK2/STAT3 signaling ...
Meiqing Shi +2 more
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ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway [PDF]
Frontiers in Immunology, 2021 J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken.
Xiquan Zhang +2 more
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gga-miR-148a-5p-Targeting PDPK1 Inhibits Proliferation and Cell Cycle Progression of Avain Leukosis Virus Subgroup J (ALV-J)-Infected Cells [PDF]
Frontiers in Cell and Developmental Biology, 2020 Avian leukosis virus subgroup J disease (ALV-J) is a contagious and immunosuppressive avian disease caused by ALV-J virus. Although miRNA participate in various biological processes of tumors, little is known about the potential role of miRNA in ALV-J ...
Huadong Yin, Yuxiang Lu, Xu Hengyong
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Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol [PDF]
Viruses, 2019 The avian leukosis virus subgroup J (ALV-J) belongs to the chicken retrovirus that causes enormous economic losses in the poultry industry. Interferon-stimulated genes (ISGs) are critical for controlling virus infections.
Min Feng, Meiqing Shi, Xiquan Zhang
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Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy [PDF]
Frontiers in Immunology, 2023 Autophagy plays an important role in host antiviral defense. The avian leukosis virus subgroup J (ALV-J) has been shown to inhibit autophagy while promoting viral replication. The underlying autophagic mechanisms, however, are unknown.
Tingting Xie +16 more
doaj +2 more sources
ALV-miRNA-p19-01 Promotes Viral Replication via Targeting Dual Specificity Phosphatase 6
Viruses, 2022 MicroRNAs (miRNAs) are a group of regulatory noncoding RNAs, serving as major regulators with a sequence-specific manner in multifarious biological processes.
Qingmei Xie +2 more
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Differential DNA Methylation and Gene Expression Between ALV-J-Positive and ALV-J-Negative Chickens [PDF]
Frontiers in Veterinary Science, 2021 Background: Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus that causes serious economic losses in the poultry industry; unfortunately, there is no effective vaccine against ALV-J.
Yiming Yan +19 more
doaj +2 more sources
Revealing novel and conservative CD8+T-cell epitopes with MHC B2 restriction on ALV-J [PDF]
Veterinary ResearchMHC B2 haplotype chickens have been reported to induce strong immune response against various avian pathogens. However, little is known about the CD8+T-cell epitope with MHC B2-restricted on subgroup J avian leukosis virus (ALV-J).
Xueqing Li +6 more
doaj +2 more sources
Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication [PDF]
Journal of VirologyAvian leukosis virus subgroup J (ALV-J) poses a significant threat to the poultry industry; yet, our understanding of its replication and pathogenic mechanisms is limited.
Shihao Chen +9 more
doaj +2 more sources