Knockout of p53 leads to a significant increase in ALV-J replication. [PDF]
Poult Sci, 2021 Avian leukemia is a common malignant disease, and and its regulatory mechanism is complex. As the most extensive tumor suppressor gene in cancer research, p53 can control multiple functions such as that of DNA repair, induction of apoptosis, cell cycle arrest and so on.
Zhang H +6 more
europepmc +4 more sources
Comparative analysis of the exosomal contents of DF-1 cells infected by ALV-J. [PDF]
Vet Med (Praha), 2022 Exploration of the abnormal expression of exosomal molecules during the infection of avian leukosis virus subgroup J (ALV-J) is essential to provide a deeper understanding of the exosome's role in the viral pathogenesis involved. The study aimed to investigate the differentially expressed proteins and miRNAs of the exosomes derived from DF-1 cells ...
Yang J, Zhuang P, Cheng Z, Wang G.
europepmc +5 more sources
Critical role for ribonucleoside-diphosphate reductase subunit M2 in ALV-J-induced activation of Wnt/β-catenin signaling via interaction with P27 [PDF]
Journal of Virology, 2023 Yung-Fu Chang, , Xinheng Zhang
exaly +2 more sources
CCL4 participates in the reprogramming of glucose metabolism induced by ALV-J infection in chicken macrophages. [PDF]
Front Microbiol, 2023 Interferon and chemokine-mediated immune responses are two general antiviral programs of the innate immune system in response to viral infections and have recently emerged as important players in systemic metabolism. This study found that the chemokine CCL4 is negatively regulated by glucose metabolism and avian leukosis virus subgroup J (ALV-J ...
Wu H +10 more
europepmc +4 more sources
Poultry Science, 2021 : Avian leukosis virus subgroup J (ALV-J) is an avian oncogenic retrovirus that has caused huge economic losses in the poultry industry due to its great pathogenicity and transmission ability.
Houkun Wang +9 more
doaj +1 more source
Transcriptome-Wide Dynamics of m6A Methylation in Tumor Livers Induced by ALV-J Infection in Chickens. [PDF]
Front Immunol, 2022 Avian Leukosis Virus Subgroup J (ALV-J) is a tumorigenic virus with high morbidity and rapid transmission. N6-methyladenosine (m6A) is a common epigenetic modification that may be closely related to the pathogenicity of ALV-J. Currently, there are no reports on whether m6A modification is related to ALV-J induced tumor formation. In this study, we used
Zhao Q +9 more
europepmc +4 more sources
Circ_PIAS1 Promotes the Apoptosis of ALV-J Infected DF1 Cells by Up-Regulating miR-183. [PDF]
Genes (Basel), 2023 (1) Background: circRNAs are closed circular molecules with covalent bonds generated by reverse shearing, which have high stability and have different manifestations in different tissues, cells, or physiological conditions and play important roles in various disease processes and physiological processes.
Yang T +8 more
europepmc +3 more sources
Viruses, 2023 Avian leukosis (AL), caused by avian leukosis virus (ALV), is a contagious tumor disease that results in significant economic losses for the poultry industry.
Junfeng Dou +10 more
doaj +1 more source
Synergistic pathogenesis of chicken infectious anemia virus and J subgroup of avian leukosis virus
Poultry Science, 2021 : As important immunosuppressive viruses, chicken infectious anemia virus (CIAV) and subgroup J avian leukosis virus (ALV-J) have caused huge economic losses to the poultry industry globally.
Jun Zhang +10 more
doaj +1 more source
Deciphering Immune Modulation in Chickens Co-Infected with ALV-J and CIAV: A Transcriptomic Approach. [PDF]
MicroorganismsViral co-infections pose significant challenges, causing substantial economic losses worldwide in the poultry industry. Among these, avian lLeukosis virus subgroup J (ALV-J) and chicken infectious anemia virus (CIAV) are particularly concerning, as they frequently lead to co-infections in chickens, further compromising their immune defenses, increasing
Chen S +5 more
europepmc +4 more sources