Results 91 to 100 of about 134,930 (269)

Dyplomy ormiańskie w zbiorach Działu Rękopisów Zakładu Narodoweg o im. Ossolińskich

open access: yesLehahayer, 2015
In the Wrocław collections of the Zakład Narodowy im. Ossolińskich [The National Ossoliński Institution] there are 3270 diplomas among which only seventeen may be classified as documents which are associated with Armenians in any way.
Konrad Rzemieniecki
doaj  

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

open access: yesFEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring   +3 more
wiley   +1 more source

Linguistic representation of the subject sphere in military charters at the turn of the 18th – 19th centuries

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2017
The paper discusses the linguistic des­cription of the subject sphere in military charters, the main management documents, created in the registry office of Don Host province (Oblast' Voiska Donskogo) at the turn of the 18th – 19th centuries.
E.M. Sheptukhina
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Some core concepts of domain analysis

open access: yesEm Questão
This article claims that information systems should provide reliable and trustworthy information, and that this demand imply a re-orientation of information science with knowledge organization from, for example, approaches based on ...
Birger Hjørland
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Clinical placement studies on early nursing education with a focus on pedagogical methods: Qualitative document analysis

open access: yesNordic Journal of Nursing Research
The present study aimed to explore and describe how pedagogical methods are communicated within formal documents pertaining to clinical placement studies in the first year of nursing education.
Marianne Trygg Solberg   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy