Results 51 to 60 of about 1,890,998 (308)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

METHODICAL ENSURING ELECTRONIC SUBJECT ANALYSIS OF DOCUMENTS: FEATURES OF EDITING SUBJECT HEADINGS IN ABIS ABSOTHEQUE UNICODE

open access: yesVìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Bìblìotekoznavstvo, Bìblìografoznavstvo, Knigoznavstvo, 2016
The purpose of our article is consideration of questions of electronic subject analysis of documents and methodical ensuring editing subject headings in the electronic catalog.
Т. М. Бикова
doaj  

A Probabilistic Method for Hierarchical Multisubject Classification of Documents Based on Multilingual Subject Term Vocabularies

open access: yesIEEE Open Journal of the Computer Society
Hierarchical Multilabel Classification (HMC) is a challenging task in information retrieval, especially within scientific textbooks, where the objective is to allocate multiple labels adhering to a hierarchical taxonomy.
Nikolaos Makris   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The management of English language support in postgraduate business education: the CEM model (contextualisation, embedding and mapping) [PDF]

open access: yes, 2009
The paper documents the background, research and preliminary findings relating to a key area emerging in higher education institutions in the UK: providing academic language and study skills to support international students in parallel with their study ...
Porter, Elizabeth, Sloan, Diane
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Sphere of Subject of Regional Documents of 18th Century: Dynamical Aspect

open access: yesНаучный диалог, 2017
The results of a comparative analysis of ways of representation the text subject sphere in the documents on a single genre are presented. The research materials are the military charters of the middle and the end of the 18th century, which are kept in ...
E. M. Sheptukhina
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Home - About - Disclaimer - Privacy