Results 61 to 70 of about 6,047,996 (306)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Multilayer network based comparative document analysis (MUNCoDA)
MethodsX, 2020 : The proposed multilayer network-based comparative document analysis (MUNCoDA) method supports the identification of the common points of a set of documents, which deal with the same subject area.
Viktor Sebestyén +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Objective and Subjective Complexity of Document Texts
Vestnik Volgogradskogo gosudarstvennogo universiteta. Serija 2. Jazykoznanije, 2016 The article is devoted to complexity as the characteristic of the document text, and its complexity as a specific operation, the result of which can be assessed objectively and subjectively. Objective complexity of the document text contributes to the following challenges for the author: 1) in terms of content to convey new information concerning a ...
openaire +2 more sources
Genetic algorithm implementation for effective document subject search
CoRR, 2015 in ...
Vladimir K. Ivanov, Pavel I. Meskin
openaire +2 more sources
ELECTRONIC DOCUMENT AS A SUBJECT OF CRIMINAL LAW PROTECTION
Bulletin of Udmurt University. Series Economics and Law, 2022 The article is devoted to the problem of criminal legal protection of electronic documents. The information environment provides ample space for documentation, but also creates risks of safe transfer, storage of documents, their protection from unlawful modification, special attention should be paid to the criminal legal protection of official ...
openaire +2 more sources
, 2021 In this study we explore the disciplinary diversity present within subject specialties in the social sciences and humanities. Subject specialties are operationalized as textually coherent clusters of documents.
Raf Guns +2 more
core +1 more source